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Effect of periodontal treatment in pregnancy on perinatal outcomes: a systematic review and meta-analysis
- Source :
- The Journal of Maternal-Fetal & Neonatal Medicine. 34:3259-3268
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- To assess the effect of periodontal treatment during pregnancy on maternal, fetal and neonatal outcomes. This is a systematic review and meta-analysis of randomized controlled trials that evaluated the effect of treatment of periodontal diseases on pregnancy outcomes. Primary outcome was perinatal mortality. Secondary outcomes were maternal and neonatal morbidity. Outcomes were pooled using fix-effect or random effects models and presented as risk ratio (RR), or mean difference (MD), and 95% confidence interval (CI). Twenty randomized controlled trials involving 8171 participants were included in this study. Periodontal treatment during pregnancy was associated with significantly decreased risk of perinatal mortality [N = 5942; RR = 0.53 (0.30–0.93); p = .03; heterogeneity (I2) = 0%, Number needed to treat (NNT): 162]. Periodontal treatment during pregnancy reduced risks of preterm birth [N = 7335; RR = 0.78 (0.62–0.98); p = .03; I2 = 72%, NNT = 37]. Periodontal treatment during pregnancy significantly increased birthweight (gram) [N = 4708; MD = 200.79 (63.34–337.24); p = .004; I2 = 93%]. Periodontal treatment during pregnancy was not associated with preeclampsia, gestational diabetes, cesarean section, small for gestational age, or congenital malformations. Periodontal treatment during pregnancy reduces the risks of perinatal mortality and preterm birth, and improves birth weight.
- Subjects :
- medicine.medical_specialty
Periodontal treatment
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Pregnancy
law
medicine
Humans
Perinatal Mortality
Randomized Controlled Trials as Topic
Fetus
030219 obstetrics & reproductive medicine
Cesarean Section
Obstetrics
business.industry
Infant, Newborn
Pregnancy Outcome
Obstetrics and Gynecology
030206 dentistry
medicine.disease
Meta-analysis
Infant, Small for Gestational Age
Pediatrics, Perinatology and Child Health
Premature Birth
Female
business
Subjects
Details
- ISSN :
- 14764954 and 14767058
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- The Journal of Maternal-Fetal & Neonatal Medicine
- Accession number :
- edsair.doi.dedup.....ab8e19b133a128766971c02543c413e2