Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y (Adv. Sci. 24/2021)

Autonomic Nervous System In article number 2100808 by Yan Zhang, Hui Xie, and co‐workers, osteocyte neuropeptide Y (NPY)‐dependent neuronal control of bone marrow mesenchymal stem/stromal cell (BMSC) fate decision is found. Osteocyte NPY promotes bone marrow adipogenesis at the expense of osteogenesis by BMSC. Osteocyte NPY production is controlled by autonomic nervous system (ANS). γ‐Oryzanol attenuates ANS dysregulation, NPY overproduction, and bone‐fat imbalance induced by aging and estrogen deficiency. [Image: see text]