Induced formation of phenylalanine ammonia lyase and pisatin by chlorpromazine and other phenothiazine derivatives

Chlorpromazine and 16 other phenothiazine derivatives induced up to 11-fold increases in phenylalanine ammonia lyase activity and the de novo synthesis of up to 200 μg pisatin per g of pea pod tissue. The induction of phenylalanine ammonia lyase was dependent on new RNA and protein synthesis and was accompanied by increased synthesis of an array of cellular proteins.