Back to Search
Start Over
The role of testosterone and gonadotropins in arrhythmogenesis
- Source :
- Journal of the American Heart Association, 10(5):e020300, 1-3. Wiley-Blackwell, Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Year :
- 2021
-
Abstract
- Background Medical castration, gonadotropin-releasing hormone agonists, and antiandrogens have been widely applied as a treatment for prostate cancer. Sex steroid hormones influence cardiac ion channels. However, few studies have examined the proarrhythmic properties of medical castration. Methods and Results This study included 149 patients who underwent medical castration using gonadotropin-releasing hormones with/without antiandrogen for prostate cancer. The changes in the ECG findings during the therapy and associations of the electrocardiographic findings with malignant arrhythmias were studied. The QT and corrected QT (QTc) intervals prolonged during the therapy compared with baseline (QT, 394±32 to 406±39 ms [
- Subjects :
- Male
medicine.medical_specialty
Sudden Cardiac Death
Risk Assessment
Gonadotropin-Releasing Hormone
Electrocardiography
Japan
Risk Factors
Internal medicine
Sex differences
medicine
Humans
Testosterone
Castration
Torsade de pointes
Original Research
Aged
Retrospective Studies
business.industry
Editorials
Prostatic Neoplasms
Androgen Antagonists
Arrhythmias, Cardiac
Testosterone (patch)
Electrophysiology
Editorial
Endocrinology
QT interval electrocardiography
Ventricular Fibrillation
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 20479980
- Database :
- OpenAIRE
- Journal :
- Journal of the American Heart Association, 10(5):e020300, 1-3. Wiley-Blackwell, Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Accession number :
- edsair.doi.dedup.....abb711110efe1685e7d465500e4376e8