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Synergistic antipseudomonal effects of synthetic peptide AMP38 and carbapenems
- Source :
- Molecules; Volume 21; Issue 9; Pages: 1223, Recercat. Dipósit de la Recerca de Catalunya, instname, Molecules, Molecules, Vol 21, Iss 9, p 1223 (2016), Dipòsit Digital de la UB, Universidad de Barcelona
- Publication Year :
- 2016
- Publisher :
- MDPI, 2016.
-
Abstract
- The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or alteration of protein OprD. Time-kill and minimal biofilm eradication concentration (MBEC) determinations were carried out by using clinical imipenem-resistant strains. AMP38 was markedly synergistic with imipenem when determined in imipenem-resistant P. aeruginosa. MBEC obtained for the combination of AMP38 and imipenem was of 62.5 μg/mL, whereas the MBEC of each antimicrobial separately was 500 μg/mL. AMP38 should be regarded as a promising antimicrobial to fight MDR P. aeruginosa infections. Moreover, killing effect and antibiofilm activity of AMP38 plus imipenem was much higher than that of colistin plus imipenem.
- Subjects :
- 0301 basic medicine
Imipenem
030106 microbiology
Antimicrobial peptides
Pharmaceutical Science
Peptide
Antibiòtics
Biology
medicine.disease_cause
Article
biofilm eradication
Analytical Chemistry
Microbiology
lcsh:QD241-441
antimicrobial peptides
03 medical and health sciences
lcsh:Organic chemistry
Antibiotics
synergism
Pseudomonas
Drug Discovery
medicine
polycyclic compounds
Physical and Theoretical Chemistry
chemistry.chemical_classification
Pseudomonas aeruginosa
Organic Chemistry
Biofilm
biochemical phenomena, metabolism, and nutrition
Antimicrobial
biology.organism_classification
bacterial infections and mycoses
Síntesi de pèptids
030104 developmental biology
Peptide synthesis
Carbapenems
chemistry
Chemistry (miscellaneous)
Biofilms
Colistin
Molecular Medicine
Pèptids
Peptides
Antimicrobial Cationic Peptides
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Molecules; Volume 21; Issue 9; Pages: 1223, Recercat. Dipósit de la Recerca de Catalunya, instname, Molecules, Molecules, Vol 21, Iss 9, p 1223 (2016), Dipòsit Digital de la UB, Universidad de Barcelona
- Accession number :
- edsair.doi.dedup.....abc137d6cc5775772a1016441aa1b214