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Prognostic role of aberrant mTOR activation in patients with stage II and III colorectal cancer
- Source :
- Biomarkers in medicine. 14(12)
- Publication Year :
- 2020
-
Abstract
- Aim: This study aimed to develop an effective risk predictor for patients with stage II and III colorectal cancer (CRC). Materials & methods: The prognostic value of p-mTOR (Ser2448) levels was analyzed using Kaplan–Meier survival analysis and Cox regression analysis. Results: The levels of p-mTOR were increased in CRC specimens and significantly correlated with poor prognosis in patients with stage II and III CRC. Notably, the p-mTOR level was an independent poor prognostic factor for disease-free survival and overall survival in stage II CRC. Conclusion: Aberrant mTOR activation was significantly associated with the risk of recurrence or death in patients with stage II and III CRC, thus this activated proteins that may serve as a potential biomarker for high-risk CRC.
- Subjects :
- 0301 basic medicine
Oncology
Adult
Male
medicine.medical_specialty
Adolescent
Colorectal cancer
Clinical Biochemistry
Stage ii
Disease-Free Survival
03 medical and health sciences
Young Adult
0302 clinical medicine
Internal medicine
Drug Discovery
medicine
Biomarkers, Tumor
Humans
In patient
Survival analysis
PI3K/AKT/mTOR pathway
Aged
Neoplasm Staging
Aged, 80 and over
Proportional hazards model
business.industry
TOR Serine-Threonine Kinases
Biochemistry (medical)
Middle Aged
medicine.disease
Prognosis
digestive system diseases
030104 developmental biology
030220 oncology & carcinogenesis
Potential biomarkers
Colonic Neoplasms
Biomarker (medicine)
Female
Neoplasm Recurrence, Local
business
Colorectal Neoplasms
Subjects
Details
- ISSN :
- 17520371
- Volume :
- 14
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Biomarkers in medicine
- Accession number :
- edsair.doi.dedup.....abc4e3932416e6f37934b62453bd1d38