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Serum ferritin as a predictive biomarker in COVID-19. A systematic review, meta-analysis and meta-regression analysis
- Source :
- Journal of Critical Care
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Ferritin is a known inflammatory biomarker in COVID-19. However, many factors and co-morbidities can confound the level of serum ferritin. This current metaanalysis evaluates serum ferritin level in different severity levels in COVID-19. Studies evaluating serum ferritin level in different clinical contexts (COVID-19 vs. control, mild to moderate vs. severe to critical, non-survivor vs. survivor, organ involvement, ICU and mechanical ventilation requirement) were included (total 9 literature databases searched). Metaanalysis and metaregression was carried out using metaphor “R” package. Compared to control (COVID-19 negative), higher ferritin levels were found among the COVID-19 patients [SMD −0.889 (95% C.I. −1.201, −0.577), I2 = 85%]. Severe to critical COVID-19 patients showed higher ferritin levels compared to mild to moderate COVID-19 patients [SMD 0.882 (0.738, 1.026), I2 = 85%]. In meta-regression, high heterogeneity was observed could be attributed to difference in “mean age”, and “percentage of population with concomitant co-morbidities”. Non-survivors had higher serum ferritin level compared to survivors [SMD 0.992 (0.672, 1.172), I2 = 92.33%]. In meta-regression, high heterogeneity observed could be attributed to difference in “mean age” and “percentage of male sex”. Patients requiring ICU [SMD 0.674 (0.515 to 0.833), I2 = 80%] and mechanical ventilation [SMD 0.430 (0.258, 0.602), I2 = 32%] had higher serum ferritin levels compared to those who didn't. To conclude, serum ferritin level may serve as an important biomarker which can aid in COVID-19 management. However, presence of other co-morbid conditions/confounders warrants cautious interpretation.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Population
Critical Care and Intensive Care Medicine
Gastroenterology
Article
SMD, Standardized mean difference
Internal medicine
Diagnosis
Humans
Medicine
Meta-regression
education
SARS-CoV2, Severe acute respiratory distress syndrome corona virus 2
Mechanical ventilation
Ferritin
education.field_of_study
biology
business.industry
MD, Mean difference
Confounding
COVID-19
Biomarker
Hyperferritin
Prognosis
Concomitant
Meta-analysis
SARS-CoV2
Ferritins
biology.protein
Regression Analysis
Biomarker (medicine)
COVID-19, Corona virus disease 2019
business
Biomarkers
Subjects
Details
- ISSN :
- 08839441
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Journal of Critical Care
- Accession number :
- edsair.doi.dedup.....abc62051b1c7410d599c281181fd025a