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Rise in morning saliva cortisol is associated with abdominal obesity in men: A preliminary report
- Source :
- Journal of Endocrinological Investigation. 26:616-619
- Publication Year :
- 2003
- Publisher :
- Springer Science and Business Media LLC, 2003.
-
Abstract
- An abnormal regulation of the hypothalamic-pituitary-adrenal (HPA) axis is associated with risk factors for cardiovascular disease and Type 2 diabetes mellitus. The objective of this study was to examine if morning saliva cortisols show similar associations. Twenty-eight men, all 53 yr of age, delivered during an ordinary working day saliva cortisol samples immediately upon awakening and 15 min thereafter as well as at different times during the day, including after a standardized lunch. Dexamethasone (0.5 mg) suppression of cortisol was also measured. The rise of morning cortisol values was positively associated with body mass index (r: 0.45, p=0.016), waist/hip ratio (r: 0.54, p=0.003), abdominal sagittal diameter (r: 0.54, p=0.003), glucose (r: 0.54, p=0.003), insulin (r: 0.57, p=0.002) and triglycerides (r: 0.46, p=0.014). The morning rise also correlated positively with the elevation of cortisol following lunch (r: 0.45, p=0.043) but not with other cortisol measurements or dexamethasone suppression. Elevation of cortisol immediately after awakening has previously been found to provide a simple indicator of HPA axis regulation, as suggested also by the results of this study, and an elevated rise has been reported after exposure to frequent or chronic perceived stress. The rise of cortisol immediately after awakening might be an indicator of an increased risk of developing serious, prevalent diseases via the metabolic syndrome.
- Subjects :
- Male
medicine.medical_specialty
Saliva
Cortisol awakening response
Hydrocortisone
Endocrinology, Diabetes and Metabolism
Blood Pressure
Risk Assessment
Dexamethasone
Body Mass Index
Cohort Studies
Eating
Endocrinology
Internal medicine
Abdomen
Humans
Medicine
Obesity
Abdominal obesity
Morning
Anthropometry
business.industry
Middle Aged
medicine.disease
medicine.symptom
Metabolic syndrome
business
Body mass index
Glucocorticoid
medicine.drug
Subjects
Details
- ISSN :
- 17208386 and 03914097
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Endocrinological Investigation
- Accession number :
- edsair.doi.dedup.....abca05d42550a6ae39ce508a41dcb65b