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Expansion of CD56- NK cells in chronic HCV/HIV-1 co-infection: reversion by antiviral treatment with pegylated IFNalpha and ribavirin
- Source :
- Clinical immunology (Orlando, Fla.). 128(1)
- Publication Year :
- 2008
-
Abstract
- Co-infection with HCV and HIV-1 is a problem of increasing importance and the role of innate cellular immunity in this co-infection is incompletely understood. Here, we have observed sharply elevated numbers of CD56(-)CD16(+) perforin(low) NK cells in HCV/HIV-1 co-infected subjects on antiretroviral therapy. Interestingly, this expansion of unconventional CD56(-) NK cells rapidly reverted when HCV was suppressed by IFNalpha and ribavirin treatment, and was not seen in mono-infected control groups. In vitro experiments suggested that this effect of treatment was due to suppression of HCV viremia rather than a direct effect of IFNalpha on these cells. In contrast, the conventional CD56(+) NK cells were largely unchanged in subjects with high HCV loads, although they exhibited slightly decreased perforin expression. With delayed kinetics, the CD56(bright) immuno-regulatory NK cell subset temporarily increased to supranormal levels in response to HCV treatment. In contrast to the NK compartment, the CD1d-restricted NKT cells were severely reduced by the co-infection and not restored by treatment. Together, our data suggest that the high HCV loads in HCV/HIV-1 co-infection alter the NK cell compartment in a way not observed in HCV mono-infection.
- Subjects :
- Adult
Male
Cellular immunity
Immunology
Viremia
HIV Infections
Interferon alpha-2
Antiviral Agents
Natural killer cell
Polyethylene Glycols
chemistry.chemical_compound
Interferon
Ribavirin
medicine
Immunology and Allergy
Humans
Aged
biology
virus diseases
Interferon-alpha
Hepatitis C, Chronic
Middle Aged
medicine.disease
Natural killer T cell
Flow Cytometry
Virology
digestive system diseases
CD56 Antigen
Lymphocyte Subsets
Recombinant Proteins
Killer Cells, Natural
medicine.anatomical_structure
Perforin
chemistry
CD1D
biology.protein
HIV-1
Female
medicine.drug
Subjects
Details
- ISSN :
- 15217035
- Volume :
- 128
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical immunology (Orlando, Fla.)
- Accession number :
- edsair.doi.dedup.....abccf32694c34939efef98b094788baa