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Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization
- Source :
- ACS medicinal chemistry letters. 3(4)
- Publication Year :
- 2011
-
Abstract
- In this paper we describe a series of 3-cyano-5-aryl-7-aminopyrazolo[1,5-a]pyrimidine hits identified by kinase-focused subset screening as starting points for the structure-based design of conformationally constrained 6-acetamido-indole inhibitors of CK2. The synthesis, SAR, and effects of this novel series on Akt signaling and cell proliferation in vitro are described.
Details
- ISSN :
- 19485875
- Volume :
- 3
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- ACS medicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....abfa52ac8e6cd286b6d945581e9ee119