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SARS-CoV-2 neutralising antibody testing in Europe: towards harmonisation of neutralising antibody titres for better use of convalescent plasma and comparability of trial data
- Source :
- Eurosurveillance, Eurosurveillance, European Centre for Disease Prevention and Control, 2021, 26 (27), ⟨10.2807/1560-7917.ES.2021.26.27.2100568⟩, EUROSURVEILLANCE, Euro surveillance, 27:2100568. Centre Europeen pour la Surveillance Epidemiologique du SIDA
- Publication Year :
- 2021
-
Abstract
- We compared the performance of SARS-CoV-2 neutralising antibody testing between 12 European laboratories involved in convalescent plasma trials. Raw titres differed almost 100-fold differences between laboratories when blind-testing 15 plasma samples. Calibration of titres in relation to the reference reagent and standard curve obtained by testing a dilution series reduced the inter-laboratory variability ca 10-fold. The harmonisation of neutralising antibody quantification is a vital step towards determining the protective and therapeutic levels of neutralising antibodies. ispartof: EUROSURVEILLANCE vol:26 issue:27 ispartof: location:Sweden status: published
- Subjects :
- 0301 basic medicine
2019-20 coronavirus outbreak
Convalescent plasma
Coronavirus disease 2019 (COVID-19)
Epidemiology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
[SDV]Life Sciences [q-bio]
Neutralising antibody
standardisation
Antibodies, Viral
MESH: Antibodies, Neutralizing
03 medical and health sciences
0302 clinical medicine
Virology
Medicine and Health Sciences
Medicine
MESH: COVID-19
Humans
MESH: SARS-CoV-2
neutralising antibodies
COVID-19 Serotherapy
Science & Technology
MESH: Humans
Plasma samples
biology
business.industry
SARS-CoV-2
Public Health, Environmental and Occupational Health
Immunization, Passive
COVID-19
standardisation, COVID-19
Antibodies, Neutralizing
3. Good health
Europe
030104 developmental biology
Infectious Diseases
030220 oncology & carcinogenesis
Immunology
convalescent plasma
biology.protein
MESH: Immunization, Passive
MESH: Europe
Antibody
business
Life Sciences & Biomedicine
Rapid Communication
MESH: Antibodies, Viral
Subjects
Details
- Language :
- English
- ISSN :
- 15607917 and 1025496X
- Database :
- OpenAIRE
- Journal :
- Eurosurveillance, Eurosurveillance, European Centre for Disease Prevention and Control, 2021, 26 (27), ⟨10.2807/1560-7917.ES.2021.26.27.2100568⟩, EUROSURVEILLANCE, Euro surveillance, 27:2100568. Centre Europeen pour la Surveillance Epidemiologique du SIDA
- Accession number :
- edsair.doi.dedup.....ac12923fc56e4277564fbe0d891f24bf