Incremental value of three-dimensional strain imaging in Danon disease

A 43-year-old woman with a familial history of Danon disease and early sudden death was clinically followed because of carrier of LAMP-2 mutation. She was symptomatic for palpitations. Clinical evaluation and electrocardiogram were normal ( Panel A ), while Holter monitoring revealed non-sustained ventricular tachycardia (VT; Panel B ). Conventional two- and three-dimensional echocardiograms were unremarkable (see Supplementary …