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Urine Proteomics Revealed a Significant Correlation Between Urine-Fibronectin Abundance and Estimated-GFR Decline in Patients with Bardet-Biedl Syndrome
- Source :
- Kidney & blood pressure research 43 (2018): 389–405. doi:10.1159/000488096, info:cnr-pdr/source/autori:Caterino M.; Zacchia M.; Costanzo M.; Bruno G.; Arcaniolo D.; Trepiccione F.; Sicilianog R.A.; Mazzeo M.F.; Ruoppolo M.; Capasso G./titolo:Urine proteomics revealed a significant correlation between urine-Fibronectin abundance and estimated-GFR decline in patients with bardet-Biedl syndrome/doi:10.1159%2F000488096/rivista:Kidney & blood pressure research/anno:2018/pagina_da:389/pagina_a:405/intervallo_pagine:389–405/volume:43, Kidney & Blood Pressure Research, Vol 43, Iss 2, Pp 389-405 (2018)
- Publication Year :
- 2018
- Publisher :
- S. Karger AG, 2018.
-
Abstract
- Background:/Aims: Renal disease is a common cause of morbidity in patients with Bardet-Biedl syndrome (BBS), however the severity of kidney dysfunction is highly variable. To date, there is little information on the pathogenesis, the risk and predictor factors for poor renal outcome in this setting. The present study aims to analyze the spectrum of urinary proteins in BBS patients, in order to potentially identify 1) disease-specific proteomic profiles that may differentiate the patients from normal subjects; 2) urinary markers of renal dysfunction. Methods: Fourteen individuals (7 males and 7 females) with a clinical diagnosis of BBS have been selected in this study. A pool of 10 aged-matched males and 10 aged-matched females have been used as controls for proteomic analysis. The glomerular filtration rate (eGFR) has been estimated using the CKD-EPI formula. Variability of eGFR has been retrospectively assessed calculating average annual eGFR decline (ΔeGFR) in a mean follow-up period of 4 years (3-7). Results: 42 proteins were significantly over- or under-represented in BBS patients compared with controls; the majority of these proteins are involved in fibrosis, cell adhesion and extracellular matrix organization. Statistic studies revealed a significant correlation between urine fibronectin (u-FN) (r2=0.28; p2 =0.35; p20.27; p2 =0.2389; pConclusion: The present study demonstrates that urine proteome of BBS patients differs from that of normal subjects; in addition, kidney dysfunction correlated with urine abundance of known markers of renal fibrosis.
- Subjects :
- Adult
Male
Proteomics
0301 basic medicine
lcsh:Diseases of the circulatory (Cardiovascular) system
·Urine proteome
medicine.medical_specialty
Proteome
Urinary system
030232 urology & nephrology
Renal function
Urine
lcsh:RC870-923
Gastroenterology
Pathogenesis
Young Adult
Urine proteome
03 medical and health sciences
0302 clinical medicine
Bardet–Biedl syndrome
Fibrosis
Internal medicine
lcsh:Dermatology
medicine
Renal fibrosis
Humans
Kidney dysfunction
Fibronectin
business.industry
General Medicine
lcsh:RL1-803
Middle Aged
lcsh:Diseases of the genitourinary system. Urology
medicine.disease
Fibronectins
030104 developmental biology
lcsh:RC666-701
Nephrology
Case-Control Studies
GFR decline
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Bardet-biedl syndrome
Glomerular Filtration Rate
Extracellular matrix organization
Subjects
Details
- ISSN :
- 14230143 and 14204096
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Kidney and Blood Pressure Research
- Accession number :
- edsair.doi.dedup.....ac34eef51d8eb91166a56abd31b73bd2