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The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum
- Source :
- Cold Spring Harb Perspect Biol, Cold Spring Harbor perspectives in biology, vol 11, iss 9, Karagöz, G Elif; Acosta-Alvear, Diego; & Walter, Peter. (2019). The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum.. Cold Spring Harbor perspectives in biology, a033886-a033886. doi: 10.1101/cshperspect.a033886. UCSF: Retrieved from: http://www.escholarship.org/uc/item/80r6147q
- Publication Year :
- 2019
- Publisher :
- Cold Spring Harbor Laboratory Press, 2019.
-
Abstract
- Most of the secreted and plasma membrane proteins are synthesized on membrane-bound ribosomes on the endoplasmic reticulum (ER). They require engagement of ER-resident chaperones and foldases that assist in their folding and maturation. Since protein homeostasis in the ER is crucial for cellular function, the protein-folding status in the organelle's lumen is continually surveyed by a network of signaling pathways, collectively called the unfolded protein response (UPR). Protein-folding imbalances, or "ER stress," are detected by highly conserved sensors that adjust the ER's protein-folding capacity according to the physiological needs of the cell. We review recent developments in the field that have provided new insights into the ER stress-sensing mechanisms used by UPR sensors and the mechanisms by which they integrate various cellular inputs to adjust the folding capacity of the organelle to accommodate to fluctuations in ER protein-folding demands.
- Subjects :
- 0301 basic medicine
Protein Folding
Proteome
1.1 Normal biological development and functioning
Plasma protein binding
Saccharomyces cerevisiae
Biology
Protein Serine-Threonine Kinases
Endoplasmic Reticulum
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Underpinning research
Organelle
Endoribonucleases
Animals
Homeostasis
Humans
Endoplasmic reticulum
Cell Membrane
Membrane Proteins
Endoplasmic Reticulum Stress
Cell biology
030104 developmental biology
Membrane protein
PERSPECTIVES
Foldase
Unfolded protein response
Unfolded Protein Response
Protein folding
Generic health relevance
Signal transduction
Ribosomes
030217 neurology & neurosurgery
Molecular Chaperones
Protein Binding
Signal Transduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Cold Spring Harb Perspect Biol, Cold Spring Harbor perspectives in biology, vol 11, iss 9, Karagöz, G Elif; Acosta-Alvear, Diego; & Walter, Peter. (2019). The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum.. Cold Spring Harbor perspectives in biology, a033886-a033886. doi: 10.1101/cshperspect.a033886. UCSF: Retrieved from: http://www.escholarship.org/uc/item/80r6147q
- Accession number :
- edsair.doi.dedup.....ac35031492b339f8b53a8801d1d93efc