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IGF2BP2 rs11705701 polymorphisms are associated with prediabetes in a Chinese population: A population-based case-control study
- Source :
- Experimental and Therapeutic Medicine. 12:1849-1856
- Publication Year :
- 2016
- Publisher :
- Spandidos Publications, 2016.
-
Abstract
- Associations between insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) rs11705701, insulin receptor substrate 1 rs7578326, gastric inhibitory polypeptide receptor rs10423928 and transcription factor 7-like 2 rs12255372 gene polymorphisms with prediabetes and type 2 diabetes (T2D) have not been evaluated in the Han Chinese population. These four genetic variants were investigated for their associations with prediabetes and T2D among 490 unrelated patients with T2D, 471 patients with prediabetes and 575 healthy controls. Sequenom MassARRAY software was used to genotype the patients for these variants. The Generalized Multifactor Dimensionality Reduction method was used to analyze the gene-gene and gene-environment interactions. A breakdown analysis by gender revealed a significant association of IGF2BP2 rs11705701 with prediabetes under the dominant genetic model in females following application of the Bonferroni correction (odds ratio = 0.26; 95% confidence interval = 0.10–0.67; P=0.005). However, no significant associations were reported between any of the other three polymorphisms and T2D under any genetic models. Furthermore, there were no statistically significant gene-gene or gene-environment interactions when evaluated with the above association tests. The present case-control study reveals a significant association between IGF2BP2 rs11705701 and prediabetes in female patients.
- Subjects :
- 0301 basic medicine
Genetics
Oncology
Cancer Research
medicine.medical_specialty
Multifactor dimensionality reduction
Case-control study
030209 endocrinology & metabolism
Articles
General Medicine
Odds ratio
Type 2 diabetes
Biology
medicine.disease
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Immunology and Microbiology (miscellaneous)
Internal medicine
Genetic model
Genotype
medicine
Gastric inhibitory polypeptide receptor
Prediabetes
Subjects
Details
- ISSN :
- 17921015, 17920981, and 11705701
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Experimental and Therapeutic Medicine
- Accession number :
- edsair.doi.dedup.....ac3d97785bd50f1a761219fe386f27f3