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Gold nanoparticles spontaneously grown on cellulose nanofibrils as a reusable nanozyme for colorimetric detection of cholesterol in human serum

Authors :
Madhusudhan Alle
Rajkumar Bandi
Garima Sharma
Ramakrishna Dadigala
Seung-Hwan Lee
Jin-Chul Kim
Source :
International Journal of Biological Macromolecules. 201:686-697
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

Recently, gold nanoparticles (AuNPs) are extensively used as peroxidase mimics. However, low catalytic activity, high synthesis cost, substrate-induced aggregation in reaction medium and difficulty in recovery and reuse still remain as major challenges. Here, a novel, simple, spontaneous, and reagent-less in-situ method for the production of AuNPs using dialdehyde cellulose nanofibrils (DACNF) is proposed. AuNPs synthesis time and size were greatly influenced by aldehyde content and the optimal aldehyde content for ultra-small AuNPs (≈10 nm) was 2.1 mM/g. AuNPs@DACNFs exhibited broad-spectrum peroxidase activity and steady-state kinetics revealed their better kinetic parameters (low K

Details

ISSN :
01418130
Volume :
201
Database :
OpenAIRE
Journal :
International Journal of Biological Macromolecules
Accession number :
edsair.doi.dedup.....ac60de22afbbe67068a0992b98c14a3a