Outcome of Graft Central Thickness After Penetrating Keratoplasty

Objective To analyze the outcome of graft central thickness after penetrating keratoplasty. Design Retrospective observational cohort study. Participants Eight hundred fifty-six consecutive penetrating keratoplasties (772 patients) performed between 1992 and 2001 were analyzed and 772 were included (1 graft per patient was included). Methods Slit-lamp examination and ultrasound pachymetry. Main Outcome Measures Slit-lamp findings, intraocular pressure, and graft central thickness were recorded. Results Patients were observed for an average of 55 months. The 36- and 60-month graft survival estimates were, respectively, 77.2% and 71.0%. The average graft central thickness in successful transplants was 655 μm at 1 week, 558 μm at 1 month, 533 μm at 6 months, 538 μm at 12 months, 558 μm at 24 months, 561 μm at 36 months, and 568 μm at 5 years. At each postoperative time point, the percentage of eyes with decreased, normal, and increased graft central thickness was significantly different according to slit-lamp findings. Of the patients with increased graft thickness, 46.2% had a simple outcome (normal intraocular pressure and normal slit-lamp findings), 28.6% experienced rejection, 15.8% experienced a graft nonimmunological event, and 9.4% experienced increased intraocular pressure. At each postoperative follow-up, subsequent graft survival was significantly lower in patients with increased graft thickness as compared with patients with normal or decreased graft thickness. When analyzing only patients with simple outcome, the relative risk of graft failure was 3.3 if graft thickness was increased at 1 month ( P Conclusions In conclusion, graft central thickness assessed by ultrasound pachymetry is a useful method for observing patients who have undergone penetrating keratoplasty. Even when slit-lamp examination reveals no complications, patients with an increase in graft thickness above the upper limit of normal for the postoperative time point under consideration are at greater risk of failure.