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Problem Based Review: The patient who has taken an overdose of long-acting insulin analogue

Authors :
K F Hunt
Omar G Mustafa
Benjamin Whitelaw
A E Eldred
Source :
Scopus-Elsevier
Publication Year :
2013
Publisher :
Rila Publications Ltd, 2013.

Abstract

Insulin overdose can cause harm due to hypoglycaemia, effects on electrolytes and acute hepatic injury. The established long-acting insulin analogue preparations (detemir and glargine) can present specific management problems because, in overdose, their effects are extremely prolonged, often lasting 48-96 hours. The primary treatment is continuous intravenous 10% or 20% glucose infusion with frequent capillary blood glucose monitoring. Surgical excision of the insulin injection site has been used successfully, even days after the overdose occurred. Once the effects of overdose have receded, diabetes treatment must be restarted with care, especially in patients with type 1 diabetes. Monitoring serum insulin concentration has been successfully used to predict when the effects of the overdose will cease.

Details

ISSN :
17474884
Volume :
12
Database :
OpenAIRE
Journal :
Acute Medicine Journal
Accession number :
edsair.doi.dedup.....ac851b611626273860ea73e474a8a3f2
Full Text :
https://doi.org/10.52964/amja.0312