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Scalable Low-Cost Fabrication of Disposable Paper Sensors for DNA Detection
- Source :
- ACS Applied Materials & Interfaces
- Publication Year :
- 2014
- Publisher :
- American Chemical Society (ACS), 2014.
-
Abstract
- Controlled integration of features that enhance the analytical performance of a sensor chip is a challenging task in the development of paper sensors. A critical issue in the fabrication of low-cost biosensor chips is the activation of the device surface in a reliable and controllable manner compatible with large-scale production. Here, we report stable, well-adherent, and repeatable site-selective deposition of bioreactive amine functionalities and biorepellant polyethylene glycol-like (PEG) functionalities on paper sensors by aerosol-assisted, atmospheric-pressure, plasma-enhanced chemical vapor deposition. This approach requires only 20 s of deposition time, compared to previous reports on cellulose functionalization, which takes hours. A detailed analysis of the near-edge X-ray absorption fine structure (NEXAFS) and its sensitivity to the local electronic structure of the carbon and nitrogen functionalities. σ*, π*, and Rydberg transitions in C and N K-edges are presented. Application of the plasma-processed paper sensors in DNA detection is also demonstrated.
- Subjects :
- Paper
Materials science
Fabrication
Molecular Sequence Data
Nanotechnology
Biosensing Techniques
02 engineering and technology
Chemical vapor deposition
010402 general chemistry
Sensitivity and Specificity
01 natural sciences
X-ray absorption
NEXAFS
Deposition (phase transition)
General Materials Science
Sensitivity (control systems)
Disposable Equipment
Absorption (electromagnetic radiation)
Oligonucleotide Array Sequence Analysis
DNA detection
cellulose functionalization
Base Sequence
Reproducibility of Results
DNA
Equipment Design
021001 nanoscience & nanotechnology
Chip
paper sensors
0104 chemical sciences
Equipment Failure Analysis
Systems Integration
Surface modification
0210 nano-technology
Biosensor
Research Article
Subjects
Details
- ISSN :
- 19448252 and 19448244
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- ACS Applied Materials & Interfaces
- Accession number :
- edsair.doi.dedup.....ac96543369fe9dd24d931d54ea691ae7