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Marine Exopolysaccharide Complexed with Scandium Aimed as Theranostic Agents
- Source :
- Molecules, Vol 26, Iss 1143, p 1143 (2021), Molecules, Molecules, MDPI, 2021, 2021-02-20, 26 (4), pp.1143. ⟨10.3390/molecules26041143⟩, Molecules, 2021, 2021-02-20, 26 (4), pp.1143. ⟨10.3390/molecules26041143⟩, Volume 26, Issue 4, Molecules (1420-3049) (MDPI AG), 2021-02, Vol. 26, N. 4, P. 1143 (23p.)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- (1) Background: Exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium, showed anti-metastatic properties. They may represent a new class of ligands to be combined with theranostic radionuclides, such as 47Sc/44Sc. The goal of this work was to investigate the feasibility of such coupling. (2) Methods: EPSs, as well as heparin used as a drug reference, were characterized in terms of molar mass and dispersity using Asymmetrical Flow Field-Flow Fractionation coupled to Multi-Angle Light Scattering (AF4-MALS). The intrinsic viscosity of EPSs at different ionic strengths were measured in order to establish the conformation. To determine the stability constants of Sc with EPS and heparin, a Free-ion selective radiotracer extraction (FISRE) method has been used. (3) Results: AF4-MALS showed that radical depolymerization produces monodisperse EPSs, suitable for therapeutic use. EPS conformation exhibited a lower hydrodynamic volume for the highest ionic strengths. The resulting random-coiled conformation could affect the complexation with metal for high concentration. The LogK of Sc-EPS complexes have been determined and showing that they are comparable to the Sc-Hep. (4) Conclusions: EPSs are very promising to be coupled with the theranostic pair of scandium for Nuclear Medicine.
- Subjects :
- Light
Intrinsic viscosity
theranostic
complexation
Dispersity
scandium
Pharmaceutical Science
Ionic bonding
[CHIM.THER]Chemical Sciences/Medicinal Chemistry
02 engineering and technology
01 natural sciences
Theranostic Nanomedicine
Analytical Chemistry
Coordination Complexes
Drug Discovery
Carbohydrate Conformation
Scattering, Radiation
characterization
Scandium
Molar mass
Viscosity
exopolysaccharides
021001 nanoscience & nanotechnology
Fractionation, Field Flow
3. Good health
Chemistry (miscellaneous)
visual_art
visual_art.visual_art_medium
Molecular Medicine
0210 nano-technology
Inorganic chemistry
chemistry.chemical_element
Fractionation
010402 general chemistry
Article
Metal
lcsh:QD241-441
lcsh:Organic chemistry
Polysaccharides
[CHIM.COOR]Chemical Sciences/Coordination chemistry
Physical and Theoretical Chemistry
Depolymerization
Osmolar Concentration
Organic Chemistry
0104 chemical sciences
chemistry
Hydrodynamics
Nuclear Medicine
Alteromonas
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 1143
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....ac9763d581104d72bb447ca4480b33a9