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The Dmca1D channel mediates Ca(2+) inward currents in Drosophila embryonic muscles
- Source :
- Journal of neurogenetics. 29(2-3)
- Publication Year :
- 2015
-
Abstract
- We studied, in a genetic model organism, Drosophila melanogaster, the channel mechanisms underlying membrane excitation in the embryonic body wall muscle whose biophysical properties have been poorly characterized. The inward current underlying the action potential was solely mediated by a high-threshold class of voltage-gated Ca(2+) channels, which exhibited slow inactivation, Ca(2+) permeability with saturation at high [Ca(2+)]OUT, and sensitivity to a Ca(2+) channel blocker, Cd(2+). The Ca(2+) current in the embryonic muscle was completely eliminated in Dmca1D mutants, indicating that the Dmca1D-encoded Ca(2+) channel is the major mediator of inward currents in the body wall muscles throughout the embryonic and larval stages.
- Subjects :
- medicine.medical_specialty
Mutant
Membrane Potentials
Animals, Genetically Modified
Cellular and Molecular Neuroscience
Internal medicine
Genetic model
Genetics
medicine
Animals
Drosophila Proteins
Channel blocker
Muscle, Skeletal
biology
Skeletal muscle
Slow inactivation
biology.organism_classification
Embryonic stem cell
Endocrinology
medicine.anatomical_structure
Drosophila melanogaster
Permeability (electromagnetism)
Biophysics
Calcium
Calcium Channels
Ion Channel Gating
Subjects
Details
- ISSN :
- 15635260
- Volume :
- 29
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- Journal of neurogenetics
- Accession number :
- edsair.doi.dedup.....acb1e8f7340097e51ecac066eb7109e1