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The promise of single-cell sequencing
- Source :
- Nature methods. 11(1)
- Publication Year :
- 2014
-
Abstract
- Individual cells of the same phenotype are commonly viewed as identical functional units of a tissue or organ. However, the deep sequencing of DNA and RNA from single cells suggests a more complex ecology of heterogeneous cell states that together produce emergent system-level function. Continuing development of high-content, real-time, multimodal single-cell measurement technologies will lead to the ultimate goal of understanding the function of an individual cell in the context of its microenvironment.
- Subjects :
- Cancer genome sequencing
Genomics
Context (language use)
Computational biology
Biology
Biochemistry
Polymerase Chain Reaction
Deep sequencing
DNA sequencing
Transcriptome
Animals
Humans
Molecular Biology
In Situ Hybridization, Fluorescence
Genetics
Genome
Sequence Analysis, RNA
Parkinson Disease
Cell Biology
Sequence Analysis, DNA
Phenotype
Single cell sequencing
Single-Cell Analysis
Function (biology)
Biotechnology
Subjects
Details
- ISSN :
- 15487105
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature methods
- Accession number :
- edsair.doi.dedup.....ace5e524dc84643895cbf2b3c101eecc