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The role of the combination of bone and fall related risk factors on short-term subsequent fracture risk and mortality
- Source :
- BMC Musculoskeletal Disorders, 14:121. BioMed Central Ltd, BMC Musculoskeletal Disorders
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Background: We analysed whether a combination of bone-and fall-related risk factors (RFs) in addition to a recent non-vertebral fracture (NVF) contributed to subsequent NVF risk and mortality during 2-years in patients who were offered fall and fracture prevention according to Dutch fracture-and fall-prevention guidelines.Methods: 834 consecutive patients aged >= 50 years with a recent NVF who were included. We compared subgroups of patients according to the presence of bone RFs and/or fall RFs (group 1: only bone RFs; group 2: combination of bone and fall RFs; group 3: only fall RFs; group 4: no additional RFs). Univariable and multivariable Cox regression analyses were performed adjusted for age, sex and baseline fracture location (major or minor).Results: 57 (6.8%) had a subsequent NVF and 29 (3.5%) died within 2-years. Univariable Cox regression analysis showed that patients with the combination of bone and fall RFs had a 99% higher risk in subsequent fracture risk compared to all others (Hazard Ratio (HR) 1.99; 95% Confidence Interval (CI) 1.18-3.36) Multivariable analyses this was borderline not significant (HR 1.70; 95% CI: 0.99-2.93). No significant differences in mortality were found between the groups.Conclusion: Evaluation of fall RFs contributes to identifying patients with bone RFs at highest immediate risk of subsequent NVF in spite of guideline-based treatment. It should be further studied whether earlier and immediate prevention following a NVF can decrease fracture risk in patients with a combination of bone and fall RFs.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
VERTEBRAL FRACTURES
genetic structures
Sports medicine
Poison control
GUIDELINES
Fractures, Bone
Rheumatology
Risk Factors
Internal medicine
OSTEOPOROTIC FRACTURE
Epidemiology
IMPLEMENTATION
medicine
Humans
Orthopedics and Sports Medicine
Prospective Studies
skin and connective tissue diseases
Prospective cohort study
Aged
Aged, 80 and over
business.industry
Proportional hazards model
Hazard ratio
Orthopedics
MEN
Middle Aged
Confidence interval
Surgery
POSTMENOPAUSAL WOMEN
Orthopedic surgery
Accidental Falls
Female
business
Follow-Up Studies
Research Article
Subjects
Details
- ISSN :
- 14712474
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- BMC Musculoskeletal Disorders
- Accession number :
- edsair.doi.dedup.....acf651e23321ab353add91bf3dce0484