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LIVER TRANSPLANTATION IN SHORT-TELOMERE-MEDIATED HEPATOPULMONARY SYNDROME FOLLOWING BONE MARROW TRANSPLANTION, USING HCV POSITIVE ALLOGRAFTS: A CASE SERIES

Authors :
James P. Hamilton
Abdul M. Oseini
Elizabeth A. King
Aliaksei Pustavoitau
Muhammad Baraa Hammami
Russel N. Wesson
Kiyoko Oshima
Andrew M. Cameron
Ahyoung Kim
Tinsay Woreta
Benjamin Philosophe
Jacqueline Garonzik-Wang
Shane Ottmann
Mary Armanios
Ahmet Gurakar
Christian A. Merlo
Michelle C. Nguyen
Nicole Rizkalla
Source :
Liver Transpl
Publication Year :
2021

Abstract

Short telomere syndromes (STS) are the most common premature aging disorders; mutations in telomerase and other telomere maintenance genes underlie their etiology(1). Their biology is defined by short telomere length which provokes senescence and apoptosis, leading to organ failure. The majority of STS are autosomal dominant, but X-linked, de novo and recessive forms exist.

Details

Language :
English
Database :
OpenAIRE
Journal :
Liver Transpl
Accession number :
edsair.doi.dedup.....acfb20fe5e50c21d96c92e29fa6e1764