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Association between Proton Pump Inhibitors and Hearing Impairment: A Nested Case-Control Study
- Source :
- Current Issues in Molecular Biology, Vol 43, Iss 12, Pp 142-152 (2021), Current Issues in Molecular Biology, Volume 43, Issue 1, Pages 12-152
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- This study investigated the association of previous use of proton pump inhibitors (PPIs) with the rate of hearing impairment. The ≥40-year-old population in the Korean National Health Insurance Service-Health Screening Cohort was enrolled. The 6626 registered hearing-impaired patients were matched with 508,240 control participants for age, sex, income, region of residence, and index date (date of hearing impairment diagnosis). The prescription histories of PPIs were collected for 2 years before the index date. The odds ratios of the duration of PPI use for hearing impairment were analyzed using conditional logistic regression. Subgroups of age/sex and severity of hearing impairments were additionally analyzed for the relation of PPI use with hearing impairment. PPI use for 30–365 days was associated with a 1.65-times higher odds of hearing impairment (95% confidence interval (CI) = 1.47–1.86 for 30–365 days of PPI medication). PPI use for ≥365 days was also related to 1.52-times higher odds of hearing impairment (95% CI = 1.35–1.72, p &lt<br />0.001). All age and sex subgroups demonstrated a positive association between PPI use and hearing impairment. Severe hearing impairment showed consistently higher odds of a relation with PPI use. PPI use was associated with an increased rate of hearing impairment.
- Subjects :
- Adult
Male
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Databases, Factual
Hearing loss
QH301-705.5
Population
Microbiology
Insurance Coverage
03 medical and health sciences
0302 clinical medicine
cohort studies
Internal medicine
Republic of Korea
medicine
otorhinolaryngologic diseases
Humans
Biology (General)
education
Molecular Biology
Aged
hearing loss
Aged, 80 and over
education.field_of_study
Duration of Therapy
business.industry
case-control studies
Case-control study
General Medicine
Odds ratio
Middle Aged
Confidence interval
030104 developmental biology
Nested case-control study
Cohort
Female
epidemiology
medicine.symptom
proton pump inhibitors
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 14673045
- Volume :
- 43
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Current Issues in Molecular Biology
- Accession number :
- edsair.doi.dedup.....ad0e98734aad24f9a8ecadcbe8849b75