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Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE−/− Mice
Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE−/− Mice
- Source :
- Journal of Oncology, Vol 2021 (2021), Journal of Oncology
- Publication Year :
- 2021
- Publisher :
- Hindawi, 2021.
-
Abstract
- Chronic inflammation plays an essential role in the pathogenesis of abdominal aortic aneurysm (AAA), a progressive segmental abdominal aortic dilation. Chemerin, a multifunctional adipocytokine, is mainly generated in the liver and adipose tissue. The combination of chemerin and chemokine-like receptor 1 (CMKLR1) has been demonstrated to promote the progression of atherosclerosis, arthritis diseases, and Crohn’s disease. However, chemerin-9 acts as an analog of chemerin to exert an anti-inflammatory effect by binding to CMKLR1. Here, we first demonstrated that AAA exhibited higher levels of chemerin and CMKLR1 expression compared with the normal aortic tissues. Hence, we hypothesized that the chemerin/CMKLR1 axis might be involved in AAA progression. Moreover, we found that chemerin-9 treatment markedly suppressed inflammatory cell infiltration, neovascularization, and matrix metalloproteinase (MMP) expression, while increasing the elastic fibers and smooth muscle cells (SMCs) in Ang II-induced AAA in ApoE−/− mice. This demonstrated that chemerin-9 could inhibit AAA formation. Collectively, our findings indicate a potential mechanism underlying AAA progression and suggest that chemerin-9 can be used therapeutically.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Article Subject
Adipose tissue
Arthritis
Inflammation
030204 cardiovascular system & hematology
CMKLR1
Neovascularization
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Chemerin
RC254-282
biology
business.industry
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Abdominal aortic aneurysm
030104 developmental biology
Endocrinology
Oncology
biology.protein
cardiovascular system
medicine.symptom
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 16878450
- Database :
- OpenAIRE
- Journal :
- Journal of Oncology
- Accession number :
- edsair.doi.dedup.....ad27f5d72fcab269d9e0fd2fcedccb2b
- Full Text :
- https://doi.org/10.1155/2021/6629204