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An overview on the identification of MAIT cell antigens
- Source :
- Immunology and cell biology. 96(6)
- Publication Year :
- 2018
-
Abstract
- Mucosal Associated Invariant T (MAIT) cells are restricted by the monomorphic MHC class I‐like molecule, MHC‐related protein‐1 (MR1). Until 2012, the origin of the MAIT cell antigens (Ags) was unknown, although it was established that MAIT cells could be activated by a broad range of bacteria and yeasts, possibly suggesting a conserved Ag. Using a combination of protein chemistry, mass spectrometry, cellular biology, structural biology and chemistry, we discovered MAIT cell ligands derived from folic acid (vitamin B9) and from an intermediate in the microbial biosynthesis of riboflavin (vitamin B2). While the folate derivative 6‐formylpterin (6‐FP) generally inhibited MAIT cell activation, two riboflavin pathway derivatives, 5‐(2‐oxopropylideneamino)‐6‐D‐ribitylaminouracil (5‐OP‐RU) and 5‐(2‐oxoethylideneamino)‐6‐D‐ribitylaminouracil (5‐OE‐RU), were potent MAIT cell agonists. Other intermediates and derivatives of riboflavin synthesis displayed weak or no MAIT cell activation. Collectively, these studies revealed that in addition to peptide and lipid‐based Ags, small molecule natural product metabolites are also ligands that can activate T cells expressing αβ T cell receptors, and here we recount this discovery.
- Subjects :
- 0301 basic medicine
Immunology
Cell
Peptide
Mucosal associated invariant T cell
Lymphocyte Activation
Mucosal-Associated Invariant T Cells
03 medical and health sciences
0302 clinical medicine
Antigen
MHC class I
medicine
Immunology and Allergy
Animals
Humans
Antigens
chemistry.chemical_classification
biology
T-cell receptor
Cell Biology
Small molecule
3. Good health
030104 developmental biology
medicine.anatomical_structure
Biochemistry
chemistry
biology.protein
Cell activation
030215 immunology
Subjects
Details
- ISSN :
- 14401711
- Volume :
- 96
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Immunology and cell biology
- Accession number :
- edsair.doi.dedup.....ad35b548488fdd2ce0bf839356e54c6e