Single dose tinidazole prophylaxis in vaginal hysterectomy

To determine the efficacy and side effects of a single dose of tinidazole for infection following vaginal hysterectomy.A randomized double-blind placebo-controlled trial using 2 g tinidazole 12 h before vaginal hysterectomy in 50 patients was conducted. No other antibiotic was used until the development of infection.There was a significant reduction (P0.01) of post-operative vaginal cuff cellulitis (54-16%). A similar reduction (P0.05) in febrile morbidity was also observed. The duration of postoperative hospital stay (P0.001) and use of additional antibiotics (P0.01) were also reduced. No adverse effect of tinidazole was noted.A single dose of tinidazole appears to be a safe and effective alternative prevention against infection in vaginal hysterectomy.