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Co-expression of podoplanin and fibroblast growth factor 1 predicts poor prognosis in patients with lung squamous cell carcinoma
- Source :
- Molecular Medicine Reports
- Publication Year :
- 2017
- Publisher :
- Spandidos Publications, 2017.
-
Abstract
- Podoplanin and fibroblast growth factor (FGF) 1 have been detected more frequently in lung squamous cell carcinoma (SQCC) compared with lung adenocarcinoma. Furthermore, it has been previous demonstrated that FGF1 is located on the edge of tumor nests in certain lung SQCC sections, which resembles the characteristic expression pattern of podoplanin. Podoplanin and FGF1 have roles in lymphangiogenesis and angiogenesis. Based on their consistently specific expression in lung SQCC and similar localization patterns, the present study aimed to investigate whether the expression of podoplanin in tumor cells is correlated with FGF1 expression in lung SQCC and whether their co-expression has clinicopathological significance, particularly for lymphangiogenesis/angiogenesis. The correlation between podoplanin and FGF1 expression in tumor cells of 82 lung SQCC cases was investigated by immunohistochemical staining and the association between the co-expression of podoplanin and FGF1, and clinicopathological factors such as microvessel density (MVD), was examined in these samples. In addition, the prognostic value of co-expression of podoplanin and FGF1 in tumor cells was determined, and the regulation of FGF1 expression and angiogenesis by podoplanin was examined in vitro in a human lung SQCC cell line. Immunohistochemical analysis demonstrated that there was a significant correlation between podoplanin and FGF1 expression in lung SQCC tumor cells (R=0.591; P
- Subjects :
- Adult
Male
0301 basic medicine
Cancer Research
Lung Neoplasms
Angiogenesis
Adenocarcinoma of Lung
Adenocarcinoma
Biochemistry
angiogenesis
03 medical and health sciences
0302 clinical medicine
Cell Line, Tumor
lung squamous cell carcinoma
Biomarkers, Tumor
Genetics
Carcinoma
Humans
Medicine
Gene Silencing
Lymphangiogenesis
fibroblast growth factor 1
Molecular Biology
Aged
Aged, 80 and over
Tube formation
Membrane Glycoproteins
business.industry
Endothelial Cells
Cancer
Articles
Middle Aged
Prognosis
medicine.disease
co-expression
Survival Rate
podoplanin
030104 developmental biology
Oncology
Podoplanin
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Cancer research
Molecular Medicine
Immunohistochemistry
Female
business
Subjects
Details
- ISSN :
- 17913004 and 17912997
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....ad4682d76cb23ab9fc5eff6965140ce3