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Age no bar: A CIBMTR analysis of elderly patients undergoing autologous hematopoietic cell transplantation for multiple myeloma
- Source :
- Cancer
- Publication Year :
- 2020
-
Abstract
- BACKGROUND Upfront autologous hematopoietic stem cell transplantation (AHCT) remains an important therapy in the management of patients with multiple myeloma (MM), a disease of older adults. METHODS The authors investigated the outcomes of AHCT in patients with MM who were aged ≥70 years. The Center for International Blood and Marrow Transplant Research (CIBMTR) database registered 15,999 patients with MM in the United States within 12 months of diagnosis during 2013 through 2017; a total of 2092 patients were aged ≥70 years. Nonrecurrence mortality (NRM), disease recurrence and/or progression (relapse; REL), progression-free survival (PFS), and overall survival (OS) were modeled using Cox proportional hazards models with age at transplantation as the main effect. Because of the large sample size, a P value
- Subjects :
- Melphalan
Male
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Hematopoietic stem cell transplantation
Gastroenterology
Transplantation, Autologous
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
Humans
030212 general & internal medicine
Multiple myeloma
Aged
Aged, 80 and over
Dose-Response Relationship, Drug
business.industry
Proportional hazards model
Hazard ratio
Hematopoietic Stem Cell Transplantation
Middle Aged
medicine.disease
Confidence interval
Progression-Free Survival
United States
Transplantation
Treatment Outcome
Oncology
Geriatric oncology
030220 oncology & carcinogenesis
Female
Neoplasm Recurrence, Local
business
Multiple Myeloma
medicine.drug
Subjects
Details
- ISSN :
- 10970142
- Volume :
- 126
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Cancer
- Accession number :
- edsair.doi.dedup.....ad550a3a81613ed3b09f84affaf48a74