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Characterization of c-Maf Transcription Factor in Normal and Neoplastic Hematolymphoid Tissue and Its Relevance in Plasma Cell Neoplasia
- Source :
- American Journal of Clinical Pathology. 132:361-371
- Publication Year :
- 2009
- Publisher :
- Oxford University Press (OUP), 2009.
-
Abstract
- c-Maf, a leucine zipper-containing transcription factor, is involved in the t(14;16)(q32;q23) translocation found in 5% of myelomas. A causal role for c-Maf in myeloma pathogenesis has been proposed, but data on c-Maf protein expression are lacking. We therefore studied the expression of c-Maf protein by immunohistochemical analysis in myelomas and in a wide variety of hematopoietic tissue. c-Maf protein was detected in a small minority (4.3%) of myelomas, including a t(14;16)(q32;q22-23)/IgH-Maf+ case, suggesting that c-Maf protein is not expressed in the absence of c-Maf rearrangement. In contrast, c-Maf was strongly expressed in hairy cell leukemia (4/4) and in a significant proportion of T-cell (24/42 [57%]) and NK/T-cell (49/97 [51%]) lymphomas, which is in keeping with prior gene expression profiling and transgenic mouse studies. Up-regulation of c-Maf protein occurs in a small subset of myelomas, in hairy cell leukemia, and in T- and NK-cell neoplasms. Its detection may be of particular value in the differential diagnosis of small cell lymphomas.
- Subjects :
- Lymphoma
Blotting, Western
Palatine Tonsil
Gene Expression
Biology
Plasma cell
Article
immune system diseases
hemic and lymphatic diseases
Gene expression
Biomarkers, Tumor
medicine
Humans
Hairy cell leukemia
Transcription factor
In Situ Hybridization, Fluorescence
B cell
General Medicine
medicine.disease
Immunohistochemistry
Leukemia
medicine.anatomical_structure
Proto-Oncogene Proteins c-maf
Cancer research
Multiple Myeloma
Subjects
Details
- ISSN :
- 19437722 and 00029173
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- American Journal of Clinical Pathology
- Accession number :
- edsair.doi.dedup.....ad70ee8ba94109a0f5be19615366a123