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Quercetin/chitosan-graft-alpha lipoic acid micelles: A versatile antioxidant water dispersion with high stability
- Source :
- Carbohydrate polymers. 234
- Publication Year :
- 2019
-
Abstract
- Natural active compounds with antioxidant properties and other potential health benefits, like quercetin (Qu), have aroused wide concern for developing bio-functional products. However, their applications are hindered by their intrinsic poor water solubility and chemical instability. In this paper, a natural antioxidant alpha lipoic acid (ALA) was grafted onto chitosan (CS) to synthesize a novel graft polymer (CS-graft-ALA). In particular, this graft-polymer could self-assemble into spherical nanomicelles in water, with a low critical micelle concentration (CMC) of 0.0076 mg/mL. As a robust and active nanocarrier, the CS-graft-ALA micelles showed high efficiency in encapsulating Qu and dispersing Qu in water. As found, the antioxidant activity of Qu was effectively enhanced when entrapped within CS-graft-ALA micelles. Moreover, CS-graft-ALA micelles could significantly improve the photo-stability and temperature-stability of Qu. The Qu/CS-graft-ALA micelles with excellent water dispersability, stability and improved antioxidant activity hold a great potential for wide applications.
- Subjects :
- Antioxidant
Polymers and Plastics
Polymers
Surface Properties
Alpha-Lipoic Acid
medicine.medical_treatment
02 engineering and technology
010402 general chemistry
01 natural sciences
Micelle
Antioxidants
Chitosan
chemistry.chemical_compound
Picrates
Materials Chemistry
medicine
Particle Size
Micelles
Aqueous solution
Molecular Structure
Thioctic Acid
Organic Chemistry
Biphenyl Compounds
Water
021001 nanoscience & nanotechnology
0104 chemical sciences
Graft polymer
chemistry
Solubility
Critical micelle concentration
Quercetin
Nanocarriers
0210 nano-technology
Nuclear chemistry
Subjects
Details
- ISSN :
- 18791344
- Volume :
- 234
- Database :
- OpenAIRE
- Journal :
- Carbohydrate polymers
- Accession number :
- edsair.doi.dedup.....ad8ed92fcb2c6b3811d0c40a766f52d6