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A comparison of the mechanical, kinetic, and biochemical properties of fibrin clots formed with two different fibrin sealants
- Source :
- Blood Coagulation & Fibrinolysis. 22:19-23
- Publication Year :
- 2011
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2011.
-
Abstract
- The objective of the present study was to compare the mechanical, kinetic, and biochemical properties of fibrin clots produced using EVICEL Fibrin Sealant (Human) and TISSEEL Fibrin Sealant. The stiffness/elasticity and strength of fibrin clots formed with EVICEL and TISSEEL were assessed using applied mechanical force and thromboelastography (TEG). The factor XIII content of the fibrin clots was also evaluated. Mean Young modulus and tensile strength of the fibrin clots produced by EVICEL were significantly higher than those of clots produced by TISSEEL (P < 0.05 for both). The mean time to initial clot formation and mean time to the predefined level of clot formation were numerically shorter for EVICEL compared with TISSEEL. Furthermore, mean maximal amplitude of the clots formed with EVICEL was significantly greater than that for the clots formed with TISSEEL. Mean concentration of factor XIII for the EVICEL fibrinogen samples tested was 9 IU/ml compared with undetectable concentrations of factor XIII for the TISSEEL fibrinogen samples. Fibrin clots formed with EVICEL have a much higher resistance to stretching and tensile strength and are more capable of maintaining their structure against applied force than those formed with TISSEEL. EVICEL also allows more rapid development of fibrin clots than TISSEEL. This superior clot strength and resilience obtained with EVICEL relative to TISSEEL may be due in large part to the presence of factor XIII.
- Subjects :
- medicine.medical_specialty
Fibrin Tissue Adhesive
Fibrinogen
Hemostatics
Fibrin
Elastic Modulus
Tensile Strength
Ultimate tensile strength
medicine
Humans
Blood Coagulation
Factor XIII
biology
medicine.diagnostic_test
Fibrin sealants
Chemistry
Sealant
Hematology
General Medicine
Thromboelastography
Thrombelastography
Surgery
biology.protein
Clot strength
circulatory and respiratory physiology
Biomedical engineering
medicine.drug
Subjects
Details
- ISSN :
- 09575235
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Blood Coagulation & Fibrinolysis
- Accession number :
- edsair.doi.dedup.....ada111236aa735f0f4a5b5ac701d81d8