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Involvement of galanin and galanin receptor 2 in a mouse model of allergic rhinitis
- Source :
- Allergology International, Vol 71, Iss 1, Pp 83-93 (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Background: Allergic rhinitis (AR) is caused by allergic reaction to allergens such as pollen. Galanin (GAL), a neuropeptide that regulates inflammatory processes, is widely expressed in the central and peripheral nervous systems. Although neuropeptides are implicated in arthritis and chemically induced ileitis, their roles in AR remain unclear. Methods: We developed a murine model of AR and generated control, systemic sensitization, mild AR, and severe AR groups. We examined GAL and GAL receptor (GALR) mRNA and protein levels and localization patterns in each group using reverse transcription PCR, western blotting, and immunohistochemical analyses. Additionally, we evaluated the effects of M871, a GALR2 antagonist, on mice with severe AR. Results: Gal and Galr2 are expressed in nasal mucosa and brain (control) samples from control and AR mice. GAL and GALR2 were expressed at similar levels and localized to ciliated epithelial and submucosal gland cells of the nasal mucosa in all four groups. Intranasal M871 administration significantly reduced the incidence of nose rubbing behaviors and sneezing (p
- Subjects :
- medicine.medical_specialty
Neuropeptide
Mucous membrane of nose
Galanin
Biology
Immunoglobulin E
Allergic rhinitis
Mouse model
Mice
Internal medicine
medicine
Immunology and Allergy
Animals
Humans
RNA, Messenger
Receptor
Sensitization
Mice, Inbred BALB C
General Medicine
RC581-607
Rhinitis, Allergic
Receptor, Galanin, Type 2
Galanin receptor 2
Disease Models, Animal
Nasal Mucosa
Endocrinology
medicine.anatomical_structure
biology.protein
Nasal administration
Female
Immunologic diseases. Allergy
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 13238930
- Volume :
- 71
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Allergology International
- Accession number :
- edsair.doi.dedup.....ada56f5dd43c022c61a78eac444bfe83