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Protease-activated receptor 2 contributes to Toxoplasma gondii-mediated gut inflammation
- Source :
- Parasite Immunology 11 (39), . (2017), Parasite Immunology, Parasite Immunology, Wiley, 2017, 39 (11), ⟨10.1111/pim.12489⟩
- Publication Year :
- 2017
-
Abstract
- International audience; Toxoplasma gondii is a widespread intracellular parasite, which naturally enters the organism via the oral route and crosses the intestinal barrier to disseminate. In addition to neuronal and ocular pathologies, this pathogen also causes gut inflammation in a number of animals. This infection-triggered inflammation has been extensively studied in the C57BL/6 mice, highlighting the importance of the immune cells and their mediators in the development of gut pathology. However, despite their importance in inflammation, the role of protease-activated receptors (PAR) was never reported in the context of T.gondii-mediated small intestine inflammation. Using genetically modified mice, we show that PAR(2) plays a pathogenic role in the development of gut inflammatory lesions. We find that PAR(2) controls the innate inflammatory mediators IL-6, KC/CXCL1, PGE(2) as well as neutrophil infiltration in T. gondii-triggered gut damage. These results bring new knowledge on the mechanisms operating in the gut in response to T. gondii infection.
- Subjects :
- 0301 basic medicine
protease-activated receptor
ileitis
Chemokine CXCL1
Immunology
Inflammation
Biology
Dinoprostone
03 medical and health sciences
Mice
0302 clinical medicine
Immune system
parasitic diseases
Intestine, Small
medicine
gut infection
Animals
Receptor, PAR-2
Protease-activated receptor
Receptor
par
Protease-activated receptor 2
Mice, Knockout
Interleukin-6
toxoplasma gondii
Intracellular parasite
barrière intestinale
Toxoplasma gondii
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
biology.organism_classification
3. Good health
CXCL1
Mice, Inbred C57BL
Hépatologie et Gastroentérologie
030104 developmental biology
inflammation
Neutrophil Infiltration
Hépatology and Gastroenterology
lésion intestinale
Parasitology
Female
medicine.symptom
Toxoplasma
Toxoplasmosis
030215 immunology
inflammation de l'intestin
Subjects
Details
- Language :
- English
- ISSN :
- 01419838 and 13653024
- Database :
- OpenAIRE
- Journal :
- Parasite Immunology 11 (39), . (2017), Parasite Immunology, Parasite Immunology, Wiley, 2017, 39 (11), ⟨10.1111/pim.12489⟩
- Accession number :
- edsair.doi.dedup.....adabbbe3855df32a7829045996cd71b3