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Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future
- Source :
- International Journal of Molecular Sciences, Vol 21, Iss 6623, p 6623 (2020), International Journal of Molecular Sciences
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Our understanding of the tumorigenesis of classical Hodgkin lymphoma (cHL) and the formation of Reed–Sternberg cells (RS-cells) has evolved drastically in the last decades. More recently, a better characterization of the signaling pathways and the cellular interactions at play have paved the way for new targeted therapy in the hopes of improving outcomes. However, important gaps in knowledge remain that may hold the key for significant changes of paradigm in this lymphoma. Here, we discuss the past, present, and future of cHL, and review in detail the more recent discoveries pertaining to genetic instability, anti-apoptotic signaling pathways, the tumoral microenvironment, and host-immune system evasion in cHL.
- Subjects :
- 0301 basic medicine
Carcinogenesis
MAP Kinase Signaling System
medicine.medical_treatment
Telomere dysfunction
Review
TRF2
Biology
Hodgkin cells
Catalysis
Targeted therapy
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
immune system diseases
hemic and lymphatic diseases
Tumor Microenvironment
medicine
Classical Hodgkin lymphoma
Humans
Reed-Sternberg Cells
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Lamin A/C
Organic Chemistry
Molecular pathogenesis
Telomere Homeostasis
genetic instability
General Medicine
Reed–Sternberg cells
medicine.disease
Hodgkin Disease
Computer Science Applications
Lymphoma
030104 developmental biology
classical Hodgkin lymphoma
telomere dysfunction
Reed–Sternberg cell
lcsh:Biology (General)
lcsh:QD1-999
030220 oncology & carcinogenesis
Hodgkin lymphoma
Neuroscience
shelterin
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 21
- Issue :
- 6623
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....adb53bd15a51e53ba240f0526b771291