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Angiogenic and Antiangiogenic Factors in Preterm Neonates Born to Mothers with and without Preeclampsia
- Source :
- Repositório Institucional da UFRGS, Universidade Federal do Rio Grande do Sul (UFRGS), instacron:UFRGS
- Publication Year :
- 2015
- Publisher :
- Georg Thieme Verlag KG, 2015.
-
Abstract
- Background Angiogenic and antiangiogenic factors are altered in pregnant women with preeclampsia (PE), but the pattern of expression of these factors in their newborns remains unknown. Objective This study aims to measure vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) levels in preterm neonates born to mothers with PE. Methods Neonates with birth weight < 2,000 g and gestational age � 34 weeks were included and divided into the following two groups: born to mothers with PE and without PE. Blood was collected from neonates within the first 72 hours of life. VEGFand sFlt-1 levels were measured using the enzyme-linked immunosorbent assay method. Results A total of 88 neonates were included (37 born to mothers with PE and 51 born to mothers without PE), with a mean gestational age of 29.12 � 2.96 weeks and birth weight of 1,223.80 � 417.48 g. In the multivariate analysis, VEGF was 80% lower and sFlt-1 was 13.48 times higher in the group with PE. sFlt-1 concentration was higher in neonates small for gestational age (SGA) than in those appropriate for gestational age. Conclusion Higher sFlt-1 and lower VEGF levels in the group with PE, as well as higher sFlt-1 levels in SGA neonates, reflect a predominance of antiangiogenic mechanisms in PE and growth restriction.
- Subjects :
- Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
VEGF receptors
Birth weight
Nutrição pré-natal
Nutrição
sFlt-1
Enzyme-Linked Immunosorbent Assay
Gestational Age
Antiangiogenic factors
Preeclampsia
chemistry.chemical_compound
Pre-Eclampsia
Growth restriction
Pregnancy
Risk Factors
medicine
Birth Weight
Humans
Crescimento e desenvolvimento
Angiogenic factors
Vascular Endothelial Growth Factor Receptor-1
Appropriate for gestational age
biology
Obstetrics
business.industry
Infant, Newborn
Obstetrics and Gynecology
Gestational age
medicine.disease
VEGF
Pregnancy Complications
Vascular endothelial growth factor
chemistry
Multivariate Analysis
embryonic structures
Pediatrics, Perinatology and Child Health
biology.protein
Small for gestational age
Female
Recém-nascido de muito baixo peso
Prematurity
business
Infant, Premature
Subjects
Details
- ISSN :
- 10988785 and 07351631
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- American Journal of Perinatology
- Accession number :
- edsair.doi.dedup.....adb93d9844e9da1d0d8c657658e74cc9
- Full Text :
- https://doi.org/10.1055/s-0035-1552932