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Mortality according to CD4 count at start of combination antiretroviral therapy among HIV positive patients followed for up to 15 years after start of treatment: collaborative cohort study

Authors :
May, Margaret T
Vehreschild, Jorg-Janne
Trickey, Adam
Obel, Niels
Reiss, Peter
Bonnet, Fabrice
Mary-Krause, Murielle
Samji, Hasina
Cavassini, Matthias
Gill, Michael John
Shepherd, Leah C
Crane, Heidi M
d'Arminio Monforte, Antonella
Burkholder, Greer A
Johnson, Margaret M
Sobrino-Vegas, Paz
Domingo, Pere
Zangerle, Robert
Justice, Amy C
Sterling, Timothy R
Miró, José M
Sterne, Jonathan A C
Antiretroviral Therapy Cohort Collaboration (ART-CC)
University of Bristol [Bristol]
Universität zu Köln = University of Cologne
University of Copenhagen = Københavns Universitet (UCPH)
University of Amsterdam [Amsterdam] (UvA)
Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC)
Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED)
Université Bordeaux Segalen - Bordeaux 2
CHU Bordeaux [Bordeaux]
Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP)
Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)
British Columbia Centre for Excellence in HIV/AIDS
St. Paul's Hospital
Université de Lausanne = University of Lausanne (UNIL)
University of Calgary
UCL Medical School
University of Washington [Seattle]
'San Paolo' Hospital
University of Alabama [Tuscaloosa] (UA)
Royal Free London NHS Foundation Trust
Instituto Salud Carlos III
Universitat Autònoma de Barcelona (UAB)
Universität Innsbruck [Innsbruck]
Yale University [New Haven]
VA Connecticut Healthcare System
Vanderbilt University [Nashville]
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Universitat de Barcelona (UB)
Medical Research Council (Reino Unido)
Department for International Development (Reino Unido)
National Institute for Health Research (Reino Unido)
Agence Nationale de Recherches sur le sida et les hépatites virales (Francia)
Institut National de la Santé et de la Recherche Médicale (Francia)
Ministère de la Santé (Francia)
Ministero della Salute (Italia)
Ministerio de Sanidad (España)
Swiss National Science Foundation
Ministerio de Ciencia e Innovación (España)
Red de Investigación Cooperativa en Investigación en Sida (España)
Stichting HIV Monitoring (Netherlands)
Unión Europea
National Institutes of Health (Estados Unidos)
NIH - National Institute on Alcohol Abuse and Alcoholism (NIAAA) (Estados Unidos)
United States Department of Veterans Affairs
Michael Smith Foundation for Health Research
Canadian Institutes of Health Research
Veterans Health Administration
Unión Europea. Comisión Europea. 7 Programa Marco
Government of Alberta (Canadá)
Government of Columnia (Estados Unidos)
Government of the United Kingdom
Abbott
Gilead Sciences (Spain)
Tibotec-Upjohn
ViiV Healthcare
GlaxoSmithKline
Pfizer
Bristol-Myers Squibb
Roche
Boehringer Ingelheim Fonds
Merck, Sharp & Dohme
HAL UPMC, Gestionnaire
Antiretroviral Therapy Cohort Collaboration (ART-CC)
Boulle, A.
Stephan, C.
Miro, JM.
Cavassini, M.
Chêne, G.
Costagliola, D.
Dabis, F.
Monforte£££Antonella D'Arminio£££ AD.
Del Amo, J.
Van Sighem, A.
Fätkenheuer, G.
Gill, J.
Guest, J.
Haerry, DH.
Hogg, R.
Justice, A.
Shepherd, L.
Obel, N.
Crane, H.
Smith, C.
Reiss, P.
Saag, M.
Sterling, T.
Teira, R.
Williams, M.
Zangerle, R.
Sterne, J.
May, M.
Ingle, S.
Trickey, A.
Universität zu Köln
University of Copenhagen = Københavns Universitet (KU)
Université de Lausanne (UNIL)
AII - Amsterdam institute for Infection and Immunity
APH - Amsterdam Public Health
Global Health
Universitat de Barcelona
Source :
Clinical Infectious Diseases, Clinical Infectious Diseases, 2016, ⟨10.1093/cid/ciw183⟩, Dipòsit Digital de la UB, Universidad de Barcelona, Clinical Infectious Diseases, Oxford University Press (OUP), 2016, ⟨10.1093/cid/ciw183⟩, Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, Clinical Infectious Diseases, vol. 62, no. 12, pp. 1571-1577, Repisalud, Instituto de Salud Carlos III (ISCIII), Recercat. Dipósit de la Recerca de Catalunya, instname, May, M T, Vehreschild, J-J, Trickey, A, Obel, N, Reiss, P, Bonnet, F, Mary-Krause, M, Samji, H, Cavassini, M, Gill, M J, Shepherd, L C, Crane, H M, d'Arminio Monforte, A, Burkholder, G A, Johnson, M M, Sobrino-Vegas, P, Domingo, P, Zangerle, R, Justice, A C, Sterling, T R, Miró, J M & Sterne, J A C 2016, ' Mortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment : Collaborative Cohort Study ', Clinical Infectious Diseases, vol. 62, no. 12, pp. 1571-1577 . https://doi.org/10.1093/cid/ciw183, Clinical infectious diseases, 62(12), 1571-1577. Oxford University Press, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, May, M T, Vehreschild, J-J, Trickey, A, Obel, N, Reiss, P, Bonnet, F, Mary-Krause, M, Samji, H, Cavassini, M, Gill, M J, Shepherd, L, Crane, H, d'Arminio Monforte, A, Burkholder, G A, Johnson, M, Sobrino-Vegas, P, Domingo, P, Zangerle, R, Justice, A C, Sterling, T, Miro, J M, Sterne, J 2016, ' Mortality according to CD4 count at start of combination antiretroviral therapy among HIV-infected patients followed for up to 15 years after start of treatment : collaborative cohort study ', Clinical Infectious Diseases, vol. 62, no. 12, pp. 1571-1577 . https://doi.org/10.1093/cid/ciw183
Publication Year :
2016
Publisher :
HAL CCSD, 2016.

Abstract

The strong association of CD4 count at start of combination therapy with subsequent survival in HIV-infected patients diminished during the first 5 years of treatment. After 5 years, lower baseline CD4 counts were not associated with higher mortality.<br />Background. CD4 count at start of combination antiretroviral therapy (ART) is strongly associated with short-term survival, but its association with longer-term survival is less well characterized. Methods. We estimated mortality rates (MRs) by time since start of ART (

Details

Language :
English
ISSN :
10584838 and 15376591
Database :
OpenAIRE
Journal :
Clinical Infectious Diseases, Clinical Infectious Diseases, 2016, ⟨10.1093/cid/ciw183⟩, Dipòsit Digital de la UB, Universidad de Barcelona, Clinical Infectious Diseases, Oxford University Press (OUP), 2016, ⟨10.1093/cid/ciw183⟩, Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, Clinical Infectious Diseases, vol. 62, no. 12, pp. 1571-1577, Repisalud, Instituto de Salud Carlos III (ISCIII), Recercat. Dipósit de la Recerca de Catalunya, instname, May, M T, Vehreschild, J-J, Trickey, A, Obel, N, Reiss, P, Bonnet, F, Mary-Krause, M, Samji, H, Cavassini, M, Gill, M J, Shepherd, L C, Crane, H M, d'Arminio Monforte, A, Burkholder, G A, Johnson, M M, Sobrino-Vegas, P, Domingo, P, Zangerle, R, Justice, A C, Sterling, T R, Miró, J M & Sterne, J A C 2016, ' Mortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment : Collaborative Cohort Study ', Clinical Infectious Diseases, vol. 62, no. 12, pp. 1571-1577 . https://doi.org/10.1093/cid/ciw183, Clinical infectious diseases, 62(12), 1571-1577. Oxford University Press, Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, May, M T, Vehreschild, J-J, Trickey, A, Obel, N, Reiss, P, Bonnet, F, Mary-Krause, M, Samji, H, Cavassini, M, Gill, M J, Shepherd, L, Crane, H, d'Arminio Monforte, A, Burkholder, G A, Johnson, M, Sobrino-Vegas, P, Domingo, P, Zangerle, R, Justice, A C, Sterling, T, Miro, J M, Sterne, J 2016, ' Mortality according to CD4 count at start of combination antiretroviral therapy among HIV-infected patients followed for up to 15 years after start of treatment : collaborative cohort study ', Clinical Infectious Diseases, vol. 62, no. 12, pp. 1571-1577 . https://doi.org/10.1093/cid/ciw183
Accession number :
edsair.doi.dedup.....adbda86828889f6d28fe734a3880ce6f
Full Text :
https://doi.org/10.1093/cid/ciw183⟩