Back to Search
Start Over
Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference: a pilot study of obese Japanese patients with type 2 diabetes
Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference: a pilot study of obese Japanese patients with type 2 diabetes
- Source :
- Cardiovascular Diabetology, Vol 10, Iss 1, p 109 (2011), Cardiovascular Diabetology
- Publisher :
- Springer Nature
-
Abstract
- Background To examine the effects of liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, on visceral fat adiposity, appetite, food preference, and biomarkers of cardiovascular system in Japanese patients with type 2 diabetes. Methods The study subjects were 20 inpatients with type 2 diabetes treated with liraglutide [age; 61.2 ± 14.0 years, duration of diabetes; 16.9 ± 6.6 years, glycated hemoglobin (HbA1c); 9.1 ± 1.2%, body mass index (BMI); 28.3 ± 5.2 kg/m2, mean ± SD]. After improvement in glycemic control by insulin or oral glucose-lowering agents, patients were switched to liraglutide. We assessed the estimated visceral fat area (eVFA) by abdominal bioelectrical impedance analysis, glycemic control by the 75-g oral glucose tolerance test (OGTT) and eating behavior by the Japan Society for the Study of Obesity questionnaire. Results Treatment with liraglutide (dose range: 0.3 to 0.9 mg/day) for 20.0 ± 6.4 days significantly reduced waist circumference, waist/hip ratio, eVFA. It also significantly improved the scores of eating behavior, food preference and the urge for fat intake and tended to reduce scores for sense of hunger. Liraglutide increased serum C-peptide immunoreactivity and disposition index. Conclusions Short-term treatment with liraglutide improved visceral fat adiposity, appetite, food preference and the urge for fat intake in obese Japanese patients with type 2 diabetes.
- Subjects :
- Male
obesity
lcsh:Diseases of the circulatory (Cardiovascular) system
Time Factors
Endocrinology, Diabetes and Metabolism
Appetite
Pilot Projects
Type 2 diabetes
eating behavior
Body Mass Index
Japan
Glucagon-Like Peptide 1
Surveys and Questionnaires
Electric Impedance
media_common
Original Investigation
Adiposity
Glucose tolerance test
liraglutide
medicine.diagnostic_test
Middle Aged
Treatment Outcome
Female
Cardiology and Cardiovascular Medicine
medicine.drug
medicine.medical_specialty
Intra-Abdominal Fat
media_common.quotation_subject
Food Preferences
Internal medicine
Diabetes mellitus
medicine
Humans
Hypoglycemic Agents
Aged
Glycated Hemoglobin
Liraglutide
business.industry
Feeding Behavior
Glucose Tolerance Test
medicine.disease
Obesity
Endocrinology
Diabetes Mellitus, Type 2
glucagon-like peptide-1
lcsh:RC666-701
business
Body mass index
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 14752840
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Diabetology
- Accession number :
- edsair.doi.dedup.....adc10c6668f0c78782ae9d0026a57ec9
- Full Text :
- https://doi.org/10.1186/1475-2840-10-109