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Impaired vascular function in asymptomatic young adult survivors of Hodgkin Lymphoma following mediastinal radiation
- Source :
- Journal of Cancer Survivorship. 4:218-224
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Mediastinal radiation can accelerate atherosclerosis in Hodgkin lymphoma survivors (HLS), and early detection is optimal. Peripheral arterial tonometry (PAT), a non-invasive measure of endothelial function, is a surrogate marker of sub-clinical atherosclerosis. The objective of our study was to evaluate endothelial function in HLS and controls using PAT and to determine the influence of mediastinal radiation.Cross-sectional evaluation was performed on 26 HLS aged 12-30 years who were a minimum of 2 years from therapy, and their healthy age and gender matched controls. Evaluation included assessment for cardiovascular risk factors and completion of the Habitual Activity Estimation Score (HAES) questionnaire to assess activity level. Endothelial Function was measured using PAT hyperemia ratios (PAT-HR).HLS and controls were similar for baseline variables (mean age 23.3 +/- 5 yrs vs. 23.4 +/- 4.8 yrs, p = 0.92). HLS were on average 6.7 +/- 4.6 yrs post treatment. No differences in endothelial function or cardiovascular risk factors were observed between HLS and controls. However, impaired endothelial function, as evidenced by lower PAT-HR (1.67 +/- 0.39 vs. 2.03 +/- 0.37, p0.01) was seen in HLS (n = 13) who received mediastinal radiation (mean radiation dose 2,600 +/- 840 cGy) compared to controls.Impaired endothelial function was preferentially observed in HLS who received mediastinal radiation, while no difference was observed between the HLS and control groups overall. This finding, assessed using a non invasive test of endothelial function, confirms that mediastinal radiation is an additional cardiovascular risk factor in this young cohort of patients. Further studies of endothelial function in this patient population are warranted.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
Adolescent
Pilot Projects
Mediastinal Neoplasms
Radiation Tolerance
Asymptomatic
Young Adult
Risk Factors
Internal medicine
medicine
Humans
Survivors
Vascular Diseases
Young adult
Risk factor
Child
Retrospective Studies
Oncology (nursing)
business.industry
Surrogate endpoint
medicine.disease
Hodgkin Disease
Lymphoma
Peripheral
Cross-Sectional Studies
Oncology
Case-Control Studies
Cohort
Cardiology
Hodgkin lymphoma
Female
Endothelium, Vascular
medicine.symptom
business
Subjects
Details
- ISSN :
- 19322267 and 19322259
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Cancer Survivorship
- Accession number :
- edsair.doi.dedup.....adc4e4d502660787e9111e23e20a27da
- Full Text :
- https://doi.org/10.1007/s11764-010-0138-6