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Regulation of T:B cell interactions by the Inducible Costimulator molecule: Does ICOS 'induce' disease?
- Source :
- Clinical Immunology. 121:13-18
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- The Inducible Costimulator molecule (ICOS), a member of the CD28 family of costimulatory molecules, was identified in 1999 as a molecule expressed primarily on activated human T cells. Induced upon activation, ICOS appears to be an ideal target for modifying T-cell-mediated immune responses. ICOS was also found to be highly expressed on germinal center T cells, suggesting that ICOS was involved in T:B cell interactions. While ICOS has subsequently been shown to be important for both Th1 and Th2 cell activation and effector function, a central role for ICOS in the generation and maintenance of humoral immunity is emerging. In this review, we summarize the evidence that the level of ICOS expression regulates T-cell-dependent B cell responses and propose a model for the role of ICOS in diseases characterized by dysregulated humoral immunity.
- Subjects :
- Antigens, Differentiation, T-Lymphocyte
B-Lymphocytes
Cell signaling
Effector
T-Lymphocytes
Immunology
Germinal center
CD28
Cell Communication
Biology
Autoimmune Diseases
Cell biology
Inducible T-Cell Co-Stimulator Protein
Immune system
medicine.anatomical_structure
Humoral immunity
Hypersensitivity
medicine
Animals
Humans
Immunology and Allergy
B cell
Subjects
Details
- ISSN :
- 15216616
- Volume :
- 121
- Database :
- OpenAIRE
- Journal :
- Clinical Immunology
- Accession number :
- edsair.doi.dedup.....adc81f387c099d175b88497aa6ff33ed