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What Sequences on High-Field MR Best Depict Temporal Resolution of Experimental ICH and Edema Formation in Mice?
- Source :
- Journal of Biomedicine and Biotechnology, Vol 2012 (2012), Journal of Biomedicine and Biotechnology
- Publication Year :
- 2012
- Publisher :
- Hindawi Limited, 2012.
-
Abstract
- Background and Purpose. Pilot study to examine the use of T1-, T2-, and T2*-weighted images for evaluating hematoma size and extent of edema in mouse brain at high field.Methods. Following collagenase-induced intracerebral hemorrhage, nine mice were imaged at 4.7 T using T1-, T2-, and T2*-weighted images for hematoma and edema quantitation on days 1, 3, 10, and 21 after surgery. Values were compared with morphometric analysis of cryosections at the time of final MR imaging.Results. For hematoma quantitation, the Spearman correlation coefficient (r) between T1 signal change and histology was 0.70 (P<0.04) compared withr=0.61(P<0.09) for T2*. The extent of perihematomal edema formation on cryosections was well reflected on T2 withr=0.73(P<0.03).Conclusions. Within the limits of our pilot study, MR imaging on 4.7 T appears to approximate the temporal changes in hematoma and edema sizes in murine ICH well, thus laying the groundwork for longitudinal studies on hematoma resorption and edema formation.
- Subjects :
- Male
High field mr
Pathology
medicine.medical_specialty
Article Subject
lcsh:Biotechnology
Health, Toxicology and Mutagenesis
lcsh:Medicine
Brain Edema
Pilot Projects
Mice
Hematoma
lcsh:TP248.13-248.65
Edema
Genetics
Animals
Medicine
Collagenases
Molecular Biology
Cerebral Hemorrhage
Intracerebral hemorrhage
Analysis of Variance
medicine.diagnostic_test
Histocytochemistry
business.industry
lcsh:R
Magnetic resonance imaging
Histology
General Medicine
medicine.disease
Magnetic Resonance Imaging
Resorption
Mice, Inbred C57BL
Molecular Medicine
Edema formation
medicine.symptom
business
Research Article
Biotechnology
Subjects
Details
- ISSN :
- 11107251 and 11107243
- Volume :
- 2012
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedicine and Biotechnology
- Accession number :
- edsair.doi.dedup.....add4b30bc9a15ac3629e2ebd1d8287be