Constructing Chiral Diazoacetoacetates by Enantioselective Catalytic Mukaiyama Aldol Reactions

Authors :: Michael P. Doyle
Kousik Kundu
Source :: ChemInform. 37
Publication Year :: 2006
Publisher :: Wiley, 2006.
Abstract: Asymmetric catalysis of Mukaiyama aldol addition reactions of methyl 3-TMSO-2-diazo-3-butenoate 4 with aromatic aldehydes using AgF/( R )-BINAP at −20 °C produces chiral diazoacetoacetates in high chemical yields and with high enantiocontrol.

Subjects :: Inorganic Chemistry
Mukaiyama aldol addition
Aldol reaction
Chemistry
Organic Chemistry
Enantioselective synthesis
Organic chemistry
General Medicine
Physical and Theoretical Chemistry
Catalysis

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