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L-Carnosine's dose-dependent effects on muscle sympathetic nerves and blood flow
- Source :
- Neuroscience letters. 591
- Publication Year :
- 2014
-
Abstract
- L-Carnosine is synthesized in mammalian muscles and brain and affects autonomic neurotransmission and physiological phenomena. To clarify the role of l-carnosine, the effects of intraduodenal administration of l-carnosine on muscle sympathetic nerve activity (muscle-SNA) and blood flow (BF) were examined. The changes in muscle-SNA and BF were examined using electrophysiological and Doppler flowmeter in urethane-anesthetized rats. The effect of propranolol, a β-adrenergic antagonist, on the increase in muscle BF due to l-carnosine was also examined. Low dose (1μg/300g body weight [bw]) of l-carnosine increased both muscle-SNA and muscle BF, while high dese (100mg/300g bw) of l-carnosine decreased both muscle-SNA and muscle BF. Furthermore, propranolol eliminated the increase in muscle BF caused by a low dose of l-carnosine. These results suggest that l-carnosine has dose-dependent effects on muscle BF via changes in muscle-SNA, and the β-adrenergic receptor is implicated in the increase in muscle BF due to l-carnosine.
- Subjects :
- Male
medicine.medical_specialty
Sympathetic Nervous System
Adrenergic beta-Antagonists
Propranolol
Internal medicine
medicine
Animals
Rats, Wistar
Receptor
Muscle, Skeletal
Dose-Response Relationship, Drug
Chemistry
General Neuroscience
Carnosine
Antagonist
Sympathetic nerve activity
Skeletal muscle
Blood flow
body regions
Electrophysiology
Endocrinology
medicine.anatomical_structure
Regional Blood Flow
L-Carnosine
medicine.drug
Subjects
Details
- ISSN :
- 18727972
- Volume :
- 591
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....ade58f9adbbe1217e97176a39fb4417d