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Higher Levels of High-Sensitivity C-Reactive Protein Is Positively Associated with the Incidence of Hyperuricemia in Chinese Population: A Report from the China Health and Retirement Longitudinal Study
- Source :
- Mediators of Inflammation, Vol 2020 (2020), Mediators of Inflammation
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Purpose. The aim of the present cohort study was to explore the longitudinal association between high-sensitivity C-reactive protein (CRP) and hyperuricemia in Chinese population. Furthermore, we conducted subgroup analyses to explore this association according to age, sex, and body mass index. Methods. A total of 5,419 healthy participants were enrolled in the final cohort analysis. The high-sensitivity CRP level was measured by immunoturbidimetric assay. Hyperuricemia was defined as serum uric acid ≥7.0 mg/dL (416 μmol/L) in men and ≥6.0 mg/dL (357 μmol/L) in women. Multivariate logistic regression was used to analyze the association. Results. During the 4 years follow-up, 474 participants developed hyperuricemia. Compared with participants in the lowest tertile of high-sensitivity CRP, the multivariate-adjusted odds ratio (OR) (95% confidence interval [CI]) for incident hyperuricemia in the highest tertile was 1.36 (1.02, 1.82). In the subgroup analyses, high-sensitivity CRP was positively associated with the incidence of hyperuricemia after multivariate adjustments (P for trend=0.04) in women. Compared with the women in the lowest tertile of high-sensitivity CRP, the multivariate-adjusted OR (95% CI) in the highest tertile was 1.69 (1.10, 2.66). No statistically significant association was found in other subgroups. Conclusions. The findings of this prospective cohort study suggest that higher level of high-sensitivity CRP is an independent risk factor for hyperuricemia in Chinese, especially in women.
- Subjects :
- Male
medicine.medical_specialty
Longitudinal study
China
Article Subject
Immunology
Hyperuricemia
030204 cardiovascular system & hematology
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Odds Ratio
Pathology
Humans
RB1-214
Longitudinal Studies
Prospective Studies
Risk factor
Prospective cohort study
Aged
030203 arthritis & rheumatology
business.industry
Incidence (epidemiology)
Immunoturbidimetry
Incidence
Cell Biology
Odds ratio
Middle Aged
medicine.disease
Healthy Volunteers
Uric Acid
C-Reactive Protein
Multivariate Analysis
Female
business
Body mass index
Biomarkers
Cohort study
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14661861 and 09629351
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Mediators of Inflammation
- Accession number :
- edsair.doi.dedup.....ae0a739b634a86a90c5f2c128d41c5b2