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The protective effects of stress control may be mediated by increased brain levels of benzodiazepine receptor agonists
The protective effects of stress control may be mediated by increased brain levels of benzodiazepine receptor agonists
- Source :
- Brain Research. 661:127-136
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- Control over stress protects against many of the deleterious effects of stress exposure, but the endogenous mediators responsible for these prophylactic effects have remained elusive. Using behavioral pharmacology, in vitro radioligand binding and neurochemical analyses, we demonstrate that exposure to escapable stress results in brain and behavior changes reminiscent of benzodiazepine administration. The stress control group shows significant protection against picrotoxinin-induced seizures, reductions in [35S]t-butylbicyclophosphorothionate (TBPS) binding and a 3-fold increase of benzodiazepine-like substances in brain in comparison to both yoked-inescapable shock and non-shock controls. These observations suggest that coping behavior leads to the release of endogenous benzodiazepine-like compounds in brain which protect the organism from stress pathology.
- Subjects :
- Flumazenil
Male
medicine.medical_specialty
Sesterterpenes
medicine.drug_class
medicine.medical_treatment
Central nervous system
Convulsants
Endogeny
Sulfur Radioisotopes
Tritium
Hippocampus
Neuroprotection
Rats, Sprague-Dawley
Bridged Bicyclo Compounds
Radioligand Assay
Neurochemical
Escape Reaction
Seizures
Internal medicine
Convulsion
medicine
Animals
Picrotoxin
GABA-A Receptor Agonists
Receptor
Molecular Biology
Cerebral Cortex
Analysis of Variance
Electroshock
Benzodiazepine
business.industry
General Neuroscience
Brain
Strychnine
Bridged Bicyclo Compounds, Heterocyclic
Receptors, GABA-A
Rats
medicine.anatomical_structure
Endocrinology
Anticonvulsant
Neurology (clinical)
medicine.symptom
business
Stress, Psychological
Developmental Biology
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 661
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....ae0fe37aca1055465e5932814d01b35c
- Full Text :
- https://doi.org/10.1016/0006-8993(94)91189-4