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Ethnicity based variation in expression of E-cadherin in patients with squamous cell carcinoma of the oral tongue

Ethnicity based variation in expression of E-cadherin in patients with squamous cell carcinoma of the oral tongue

Authors :
Gianpaolo Tartaro
Giuseppe Troiano
Linda Boldrup
Nicola Sgaramella
Xiaolian Gu
Karin Danielsson
Giovanni Dell'Aversana Orabona
Robin Fåhraeus
Giuseppe Colella
Torben Wilms
Lotta Loljung
Fatima Ardito
Luigi Califano
Renato Franco
Karin Nylander
Philip J. Coates
Lorenzo Lo Muzio
Petra Hassellöf
Lena Norberg Spaak
Mario Santagata
Fabrizio Chirico
Sgaramella, Nicola
Wilms, Torben
Boldrup, Linda
Loljung, Lotta
Gu, Xiaolian
Coates, Philip J
Hassellöf, Petra
Califano, Luigi
Lo Muzio, Lorenzo
Fåhraeus, Robin
Norberg Spaak, Lena
Franco, Renato
Tartaro, Gianpaolo
Colella, Giuseppe
Santagata, Mario
Dell'Aversana Orabona, Giovanni
Chirico, Fabrizio
Danielsson, Karin
Troiano, Giuseppe
Ardito, Fatima
Nylander, Karin
Source :
Oncology Letters
Publication Year :
2018

Abstract

The oral tongue is the most common site for tumours within the oral cavity. Despite intense research, there has been no improvement in the survival rate for patients with oral tongue squamous cell carcinoma (OTSCC) during the last decades. Differences between oral cancer patients based on ethno-geographical distribution have been reported. The present study used immunohistochemistry to evaluate commonly used markers of cancer cell phenotypes, E-cadherin, β-catenin and cytokeratins 5 and 19, in 120 patients with OTSCC. To evaluate the impact of ethnicity, patients from Sweden and Italy were included. A higher proportion of Swedish patients exhibited high expression of E-cadherin in their tumours (P=0.039), and high levels of E-cadherin in Swedish OTSCC patients that had succumbed to their disease were associated with poor prognosis. These data demonstrated differences in the pathological characteristics of OTSCC between two different European populations. The findings emphasise the need to take ethnicity/geographical location of patients into account when comparing results from different studies of OTSCC.

Details

Language :
English
Database :
OpenAIRE
Journal :
Oncology Letters
Accession number :
edsair.doi.dedup.....ae2236ecef7f59a06cced347b29f8930