Back to Search
Start Over
Ethnicity based variation in expression of E-cadherin in patients with squamous cell carcinoma of the oral tongue
Ethnicity based variation in expression of E-cadherin in patients with squamous cell carcinoma of the oral tongue
- Source :
- Oncology Letters
- Publication Year :
- 2018
-
Abstract
- The oral tongue is the most common site for tumours within the oral cavity. Despite intense research, there has been no improvement in the survival rate for patients with oral tongue squamous cell carcinoma (OTSCC) during the last decades. Differences between oral cancer patients based on ethno-geographical distribution have been reported. The present study used immunohistochemistry to evaluate commonly used markers of cancer cell phenotypes, E-cadherin, β-catenin and cytokeratins 5 and 19, in 120 patients with OTSCC. To evaluate the impact of ethnicity, patients from Sweden and Italy were included. A higher proportion of Swedish patients exhibited high expression of E-cadherin in their tumours (P=0.039), and high levels of E-cadherin in Swedish OTSCC patients that had succumbed to their disease were associated with poor prognosis. These data demonstrated differences in the pathological characteristics of OTSCC between two different European populations. The findings emphasise the need to take ethnicity/geographical location of patients into account when comparing results from different studies of OTSCC.
- Subjects :
- 0301 basic medicine
squamous cell carcinoma
Cancer Research
Pathology
medicine.medical_specialty
Beta-catenin
03 medical and health sciences
0302 clinical medicine
Tongue
medicine
Survival rate
Cancer och onkologi
Oncogene
biology
business.industry
Cadherin
oral tongue
Cancer
E-cadherin
Articles
Cell cycle
medicine.disease
Molecular medicine
3. Good health
stomatognathic diseases
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Cancer and Oncology
biology.protein
beta catenin
ethnicity
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Oncology Letters
- Accession number :
- edsair.doi.dedup.....ae2236ecef7f59a06cced347b29f8930