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Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos
- Source :
- Dunn, E C, Sofer, T, Wang, M-J, Soare, T W, Gallo, L C, Gogarten, S M, Kerr, K F, Chen, C-Y, Stein, M B, Ursano, R J, Guo, X, Jia, Y, Yao, J, Rotter, J I, Argos, M, Cai, J, Perreira, K, Wassertheil-Smoller, S, Smoller, J W, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium & Christensen, J H 2018, ' Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos ', Journal of Psychiatric Research, vol. 99, pp. 167-176 . https://doi.org/10.1016/j.jpsychires.2017.12.010
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Although genome-wide association studies (GWAS) have identified several variants linked to depression, few GWAS of non-European populations have been performed. We conducted a genome-wide analysis of depression in a large, population-based sample of Hispanics/Latinos. Data came from 12,310 adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Past-week depressive symptoms were assessed using the 10-item Center for Epidemiological Studies of Depression Scale. Three phenotypes were examined: a total depression score, a total score modified to account for psychiatric medication use, and a score excluding anti-depressant medication users. We estimated heritability due to common variants (h2SNP), and performed a GWAS of the three phenotypes. Replication was attempted in three independent Hispanic/Latino cohorts. We also performed sex-stratified analyses, analyzed a binary trait indicating probable depression, and conducted three trans-ethnic analyses. The three phenotypes exhibited significant heritability (h2SNP = 6.3–6.9%; p = .002) in the total sample. No SNPs were genome-wide significant in analyses of the three phenotypes or the binary indicator of probable depression. In sex-stratified analyses, seven genome-wide significant SNPs (one in females; six in males) were identified, though none were supported through replication. Four out of 24 loci identified in prior GWAS were nominally associated in HCHS/SOL. There was no evidence of overlap in genetic risk factors across ancestry groups, though this may have been due to low power. We conducted the largest GWAS of depression-related phenotypes in Hispanic/Latino adults. Results underscore the genetic complexity of depressive symptoms as a phenotype in this population and suggest the need for much larger samples.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Adolescent
DISORDERS
Hispanics/Latinos
Population
Single-nucleotide polymorphism
Genome-wide association study
Article
Cohort Studies
Young Adult
03 medical and health sciences
DSM-IV
QUALITY-CONTROL
Epidemiology
Humans
Medicine
education
Biological Psychiatry
Depression (differential diagnoses)
Genetic association study
Aged
Genetic association
RISK
Depressive Disorder
education.field_of_study
Depression
business.industry
Depressive symptoms
MAJOR DEPRESSION
Hispanic or Latino
Middle Aged
Heritability
United States
PREVALENCE
INDIVIDUALS
ODDS RATIOS
Psychiatry and Mental health
030104 developmental biology
RELIABILITY
Community health
POPULATIONS
Female
business
Genome-Wide Association Study
Demography
Subjects
Details
- ISSN :
- 00223956
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Journal of Psychiatric Research
- Accession number :
- edsair.doi.dedup.....ae25f488adc256b23be2d7db9dadea82