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Synthesis of aryl cyclopropyl sulfides through copper-promoted S-cyclopropylation of thiophenols using cyclopropylboronic acid
Synthesis of aryl cyclopropyl sulfides through copper-promoted S-cyclopropylation of thiophenols using cyclopropylboronic acid
- Source :
- Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 1162-1171 (2019), Beilstein Journal of Organic Chemistry
- Publication Year :
- 2019
- Publisher :
- Beilstein Institut, 2019.
-
Abstract
- The copper-promoted S-cyclopropylation of thiophenols using cyclopropylboronic acid is reported. The procedure operates under simple conditions to afford the corresponding aryl cyclopropyl sulfides in moderate to excellent yields. The reaction tolerates substitution in ortho-, meta- and para-substitution as well as electron-donating and electron-withdrawing groups. The S-cyclopropylation of a thiophenol was also accomplished using potassium cyclopropyl trifluoroborate.
- Subjects :
- aryl cyclopropyl sulfides
Copper(II) acetate
Letter
copper catalysis
thiophenols
Thiophenol
Aryl
Potassium
Organic Chemistry
copper(II) acetate
chemistry.chemical_element
Medicinal chemistry
Copper
lcsh:QD241-441
Chemistry
chemistry.chemical_compound
lcsh:Organic chemistry
chemistry
lcsh:Q
lcsh:Science
cyclopropylboronic acid
Subjects
Details
- ISSN :
- 18605397
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Beilstein Journal of Organic Chemistry
- Accession number :
- edsair.doi.dedup.....ae29d94d61fac13b1a56843d37dddbc2
- Full Text :
- https://doi.org/10.3762/bjoc.15.113