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KRIT1 as a possible new player in melanoma aggressiveness
- Source :
- Archives of biochemistry and biophysics. 691
- Publication Year :
- 2020
-
Abstract
- Krev interaction trapped protein 1 (KRIT1) is a scaffold protein known to form functional complexes with distinct proteins, including Malcavernin, PDCD10, Rap1 and others. It appears involved in several cellular signaling pathways and exerts a protective role against inflammation and oxidative stress. KRIT1 has been studied as a regulator of endothelial cell functions and represents a determinant in the pathogenesis of Cerebral Cavernous Malformation (CCM), a cerebrovascular disease characterized by the formation of clusters of abnormally dilated and leaky blood capillaries, which predispose to seizures, neurological deficits and intracerebral hemorrhage. Although KRIT1 is ubiquitously expressed, few studies have described its involvement in pathologies other than CCM including cancer. Cutaneous melanoma represents the most fatal skin cancer due to its high metastatic propensity. Despite the numerous efforts made to define the signaling pathways activated during melanoma progression, the molecular mechanisms at the basis of melanoma growth, phenotype plasticity and resistance to therapies are still under investigation.
- Subjects :
- 0301 basic medicine
Scaffold protein
Adult
Male
Cell signaling
Inflammation
KRIT1
Melanoma
N-cadherin
Tumor suppressor
β-catenin
Biophysics
Down-Regulation
Biochemistry
NO
03 medical and health sciences
Cell Movement
Cell Line, Tumor
Medicine
Humans
Molecular Biology
KRIT1 Protein
beta Catenin
Aged
Cell Proliferation
Aged, 80 and over
Cell Nucleus
030102 biochemistry & molecular biology
business.industry
Cancer
Middle Aged
medicine.disease
030104 developmental biology
Gene Knockdown Techniques
Cutaneous melanoma
Cancer research
Melanocytes
Female
KRIT1, Melanoma, Tumor suppressor, N-cadherin, Inflammation, β-catenin
Skin cancer
medicine.symptom
Signal transduction
business
Subjects
Details
- ISSN :
- 10960384
- Volume :
- 691
- Database :
- OpenAIRE
- Journal :
- Archives of biochemistry and biophysics
- Accession number :
- edsair.doi.dedup.....ae2cb103f96ffd5aa8d720b8b7216a01